This study found that Wnt signaling in the hair follicle is crucial for coordinating the behavior of epithelial and melanocytestemcells, which drives hair regeneration and melanocyte differentiation in mice.
240 citations
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April 2011 in “Pigment Cell & Melanoma Research”
This review discusses the identification and characteristics of melanocytestemcells, emphasizing their role in hair pigmentation, greying, and skin repigmentation, but reports no new research findings.
164 citations
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February 2010 in “Journal of Cell Science”
This study demonstrates that stemcells from human foreskins, which lack hair follicles, can differentiate into melanocytes and migrate to the epidermis, potentially altering our understanding of pigmentation disorders.
PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stemcells, but minoxidil and finasteride are still the main treatments.
Adipose-derived stemcell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.
The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stemcells. Both are potential new treatments for hair loss.
New hair loss treatments include Breezula, PP405, ET-02, KX-826, GT20029, VDPHL01, and CosmeRNA, with some showing promise in reactivating stemcells and reversing greying. Breezula and VDPHL01 are highlighted as potential add-ons or alternatives to current treatments like finasteride and minoxidil.
Topical application of Eriodictyon angustifolium extract can prevent and reverse age-related beard graying and darken gray hair by increasing melanin production. Sterubin, a component of the extract, also promotes hair pigmentation and protects cells from DNA damage.