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GlossaryMelanocyte Stem Cells

specialized cells that develop into pigment-producing melanocytes

Melanocyte stem cells are specialized cells found in the hair follicles and skin that have the ability to develop into melanocytes, which are the cells responsible for producing melanin, the pigment that gives color to hair, skin, and eyes. These stem cells play a crucial role in the regeneration of melanocytes, helping to maintain pigmentation and potentially offering insights into treatments for conditions like vitiligo and age-related graying of hair.

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learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

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research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations, June 2011 in “Cell”

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

research Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation

240 citations, April 2011 in “Pigment Cell & Melanoma Research”

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

research EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling

59 citations, April 2016 in “Cell Reports”

EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.

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community Is there any new drug that looks promising ?

in Research/Science 24 upvotes 9 months ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

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