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GlossaryMelanoma Cells

cancerous cells originating in pigment-producing melanocytes

Melanoma cells are cancerous cells that originate in melanocytes, the cells responsible for producing melanin, the pigment that gives skin its color. These cells can grow uncontrollably and spread to other parts of the body, making melanoma one of the most dangerous forms of skin cancer. Early detection and treatment are crucial for improving survival rates.

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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

26 citations, July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research Finasteride Inhibits Melanogenesis Through Regulation of the Adenylate Cyclase in Melanocytes and Melanoma Cells

11 citations, February 2018 in “Archives of Pharmacal Research”

Finasteride reduces melanin production, possibly treating hyperpigmentation and melanoma, but needs more safety research.

Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

research Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

1 citations, October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products”

Ficus carica leaf extract may help treat melanoma by promoting cancer cell death without harming normal cells.

P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

research P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.

research Stimulation of Melanogenesis by Carthamus Tinctorius Floret Extract in B16F10 Murine Melanoma Cells

January 2013 in “วารสารเภสัชศาสตร์อีสาน (Isan Journal of Pharmaceutical Sciences, IJPS)”

Safflower extract increases melanin production in certain skin cells without harming them.

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community New potential hair loss treatment (news release)

in Treatment 186 upvotes 4 years ago

New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.

community Why the cure is not yet found and why it is always 5 years away? Why no hopes on PP405, GT, KX, Hair cloning, AMP, etc, etc, etc

in Chat 18 upvotes 2 months ago

Skepticism about hair loss research motivations, suggesting financial interests hinder finding a cure. Mentions treatments like minoxidil, finasteride, and dutasteride, but notes they are not cures.

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