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Glossarygp100

protein in melanocytes involved in melanin production

gp100 is a protein found in melanocytes, the cells responsible for producing the pigment melanin in the skin, hair, and eyes. It is often studied in the context of melanoma, a type of skin cancer, because it serves as a target for certain immunotherapies aimed at treating this disease.

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The Silver Locus Product (Silv/gp100/Pmel17) as a New Tool for the Analysis of Melanosome Transfer in Human Melanocyte–Keratinocyte Co-Culture

research The Silver Locus Product (Silv/gp100/Pmel17) as a New Tool for the Analysis of Melanosome Transfer in Human Melanocyte–Keratinocyte Co-Culture

68 citations, March 2008 in “Experimental dermatology”

The new assay can track and measure melanosome transfer between skin cells, confirming filopodia's role in this process.

research The Peripheral Clock Regulates Human Pigmentation

81 citations, October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain genes control the color of human hair by affecting pigment production.

research Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis

29 citations, January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

July 2023

The human scalp has different types of pigment cells in hair follicles with varying abilities to produce pigment.

The Bacterial Metabolite, Butyrate, Prolongs Anagen and Promotes Autophagy, Mitochondrial Activity, Melanogenesis and Antimicrobial Peptide Production in Human Scalp Hair Follicles

research The Bacterial Metabolite, Butyrate, Prolongs Anagen and Promotes Autophagy, Mitochondrial Activity, Melanogenesis and Antimicrobial Peptide Production in Human Scalp Hair Follicles

November 2022 in “Journal of Investigative Dermatology”

Butyrate helps hair grow longer, improves hair cell health, increases pigment production, and boosts hair's natural defenses.

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