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GlossaryInterleukin-6 family

group of cytokines crucial for immune response and inflammation

The Interleukin-6 (IL-6) family is a group of cytokines, which are small proteins important for cell signaling in the immune system. These cytokines play a crucial role in inflammation, immune response, and the regulation of metabolic, regenerative, and neural processes. For professionals, it's notable that the IL-6 family includes IL-6, IL-11, LIF, OSM, CNTF, and others, all of which signal through the gp130 receptor subunit.

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research Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis

16 citations , May 2016 in “Journal of Investigative Dermatology”

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

research ACTH as first line treatment for acute calcium pyrophosphate crystal arthritis in 14 hospitalized patients

14 citations , January 2014 in “Joint Bone Spine”

ACTH may be an effective first-line treatment for acute calcium pyrophosphate crystal arthritis.

research Hair-cycle changes in two patients taking tocilizumab

6 citations , January 2014 in “Joint Bone Spine”

Tocilizumab treatment was associated with significant hair regrowth in one patient and temporary hair loss followed by regrowth in another.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options

research Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options

19 citations , September 2019 in “Expert Opinion on Therapeutic Targets”

New treatments for hair loss may target specific pathways and generate new hair follicles.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.