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GlossaryOncostatin M

cytokine involved in inflammation and cell growth regulation

Oncostatin M (OSM) is a cytokine, a type of protein involved in cell signaling, that plays a role in inflammation, immune responses, and the regulation of cell growth. It is part of the interleukin-6 (IL-6) family and can influence processes such as wound healing and the development of certain diseases, including cancer and autoimmune disorders.

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A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

research A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

101 citations, March 2019 in “Cell Stem Cell”

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

Hair Growth Induced by Blockade of Macrophage-Derived Oncostatin M and Downstream JAK-STAT5 Signaling in Hair Follicle Stem Cells

research Hair Growth Induced by Blockade of Macrophage-Derived Oncostatin M and Downstream JAK-STAT5 Signaling in Hair Follicle Stem Cells

April 2018 in “Journal of Investigative Dermatology”

Blocking a specific immune cell signal can trigger hair growth.

Oncostatin M Is Upstream of JAK-STAT Signaling During the Murine Hair Cycle

research Oncostatin M Is Upstream of JAK-STAT Signaling During the Murine Hair Cycle

April 2016 in “Journal of Investigative Dermatology”

Blocking Oncostatin M's role in the JAK-STAT pathway can stimulate hair growth in mice.

Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis

research Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis

16 citations, January 2016 in “Journal of Investigative Dermatology”

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

TREM2+ Macrophages Inhibit Hair Growth by Producing Oncostatin M

research TREM2+ Macrophages Inhibit Hair Growth by Producing Oncostatin M

4 citations, April 2019 in “Cell Stem Cell”

Certain immune cells in the skin can stop hair from growing.

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