Human Dermal Stem Cells Differentiate Into Functional Epidermal Melanocytes
March 2010
in “
Journal of Cell Science
”
TLDR Human dermal stem cells can become functional skin pigment cells.
The study demonstrated that human dermal stem cells (DSCs) isolated from foreskin could differentiate into functional melanocytes in a 3D skin model. These DSCs exhibited self-renewal capabilities and expressed neural crest stem cell markers but not melanocyte markers initially. Upon differentiation, DSC-derived melanocytes migrated to the epidermis and expressed melanocyte markers like HMB45 and E-cadherin. The findings suggested that DSCs in the dermis could serve as a reservoir for melanocytes, potentially impacting our understanding of pigmentation disorders and offering new avenues for treatment.