Human Dermal Stem Cells Differentiate Into Functional Epidermal Melanocytes

    February 2010 in “ Journal of Cell Science
    Ling Li, Mizuho Fukunaga‐Kalabis, Hong Yu, Xiaowei Xu, Jun Kong, John Tayu Lee, Meenhard Herlyn
    TLDR Human dermal stem cells can become functional skin pigment cells.
    The study demonstrated that human dermal stem cells (DSCs) isolated from foreskin could differentiate into functional melanocytes in a 3D skin model. These DSCs exhibited self-renewal capabilities and expressed neural crest stem cell markers but not melanocyte markers initially. Upon differentiation, DSC-derived melanocytes migrated to the epidermis and expressed melanocyte markers like HMB45 and E-cadherin. The findings suggested that DSCs in the dermis could serve as a reservoir for melanocytes, potentially impacting our understanding of pigmentation disorders and offering new avenues for treatment.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 11 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community How does it feel to microneedle at 0.3mm?

      in Microneedling  17 upvotes 1 year ago
      The conversation discusses microneedling for hair loss, with one user trying 0.3mm daily without feeling pain and questioning its effectiveness. Another user suggests that 0.3mm is too shallow and recommends 0.5mm twice a week or 0.75mm once a week for hair growth.

      community Summary of Procapil video by Haircafe

      in Minoxidil  1 upvotes 1 week ago
      Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

    Similar Research

    5 / 1000+ results