1039 citations
,
February 2009 in “Nature Reviews Molecular Cell Biology”
This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.
555 citations
,
July 2001 in “Genes & Development”
This study found that Tcf3 and Lef1 differently regulate cell differentiation in multipotent skinstemcells, with Tcf3 promoting follicle-like features and Lef1, when modified, promoting sebocyte differentiation.
This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stemcells, highlighting their role in regulating skinstemcell activity.
441 citations
,
May 1996 in “Journal of Cell Science”
This study found that keratin 19 may be a marker for skinstemcells, helping to characterize these cells in different conditions and potentially explaining variations in healing rates between children and adults.
This narrative review examines the interactions between skinstemcells and their niches, finding new insights from advancements in genetic and imaging tools but reporting no new experimental results.
Human pluripotent stemcells have been used to create hair and skin, potentially offering a new solution for baldness. A user also mentioned starting finasteride but experiencing unexpected hair thinning.
Scientists have grown natural-looking hair from stemcells, potentially revolutionizing hair growth treatments. Concerns include cost, DHT resistance, and the need for future procedures.
Stress can lead to hair loss by affecting hair-follicle stemcells, and this loss is harder to recover from if one has male pattern baldness (MPB). Treatments like finasteride and minoxidil are used to address hair loss, but stress-related hair loss differs from androgenic alopecia.
Stress can cause hair to turn grey due to stemcell depletion at the hair follicle base. Treatments discussed include Minoxidil, finasteride, and RU58841 for hair loss.
Hair follicle stemcells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.
Can long-term use of Fluocinolone affect the health of hair follicles?There is no long-term human trial measuring what topical fluocinolone does to hair follicles; what is documented is the label's warning about skin atrophy with prolonged use, plus a 2007 mouse study suggesting hair-follicle bulge stem cells do not repair steroid-induced atrophy.