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    Glossary OCT4

    protein crucial for maintaining embryonic stem cell pluripotency

    OCT4, also known as Octamer-binding transcription factor 4 or POU5F1, is a protein that plays a crucial role in maintaining the self-renewal and pluripotency of embryonic stem cells. It acts as a transcription factor, meaning it helps regulate the expression of genes that are essential for the development and differentiation of cells. This protein is significant in both developmental biology and regenerative medicine, as it helps scientists understand how cells can be reprogrammed to an undifferentiated state.

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    Research 10 of 687

    1. OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases Stem Cell Research & Therapy · 2019 · 57 citations
    2. Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4 Stem cells international · 2015 · 15 citations
    3. Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice Frontiers in Endocrinology · 2020 · 14 citations
    4. ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling Stem Cell Research & Therapy · 2024
    5. Dauricine attenuates Oct4/sonic hedgehog co‐activated stemness and induces reactive oxygen species‐mediated mitochondrial apoptosis via AKT/β‐catenin signaling in human neuroblastoma and glioblastoma stem‐like cells Phytotherapy Research · 2023 · 5 citations
    6. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006 · 344 citations
    7. Human dermal stem cells differentiate into functional epidermal melanocytes Journal of Cell Science · 2010 · 164 citations
    8. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes Development · 2017 · 160 citations
    9. MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2 Stem cells · 2012 · 123 citations
    10. Induced Pluripotent Stem Cells from Human Hair Follicle Mesenchymal Stem Cells Stem Cell Reviews and Reports · 2012 · 64 citations
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