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Glossary OCT4

protein crucial for maintaining embryonic stem cell pluripotency

OCT4, also known as Octamer-binding transcription factor 4 or POU5F1, is a protein that plays a crucial role in maintaining the self-renewal and pluripotency of embryonic stem cells. It acts as a transcription factor, meaning it helps regulate the expression of genes that are essential for the development and differentiation of cells. This protein is significant in both developmental biology and regenerative medicine, as it helps scientists understand how cells can be reprogrammed to an undifferentiated state.

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research OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

57 citations , January 2019 in “Stem Cell Research & Therapy”

OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.

research Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4

15 citations , January 2015 in “Stem cells international”

This study found that erythrocytes can be generated from human hair follicle mesenchymal stem cells with OCT4 expression, potentially serving as an alternative source for transfusions.

Role of OCT4 in the Regulation of FSH-Induced Granulosa Cell Growth in Female Mice

research Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice

14 citations , January 2020 in “Frontiers in Endocrinology”

This study reports that in ovarian cell development, FSH-induced OCT4 expression is regulated through the GSK3β/β-catenin pathway mediated by the PI3K/Akt pathway.

ZO-1 Boosts the In Vitro Self-Renewal of Pre-Haematopoietic Stem Cells from OCT4-Reprogrammed Human Hair Follicle Mesenchymal Stem Cells Through Cytoskeleton Remodeling

research ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling

December 2024 in “Stem Cell Research & Therapy”

This study found that OCT4-overexpressing human hair follicle mesenchymal stem cells show promise for artificial hematopoiesis by enhancing self-renewal through cytoskeletal remodeling and the beta-catenin-dependent adherens junction pathway.

research Dauricine attenuates Oct4/sonic hedgehog co‐activated stemness and induces reactive oxygen species‐mediated mitochondrial apoptosis via AKT/β‐catenin signaling in human neuroblastoma and glioblastoma stem‐like cells

5 citations , October 2023 in “Phytotherapy Research”

This study found that dauricine, a natural compound, may inhibit cell growth and enhance apoptosis in neuroblastoma and glioblastoma by blocking the Oct4/Shh pathway and AKT/β-catenin signaling.

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