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    Glossary OCT4

    protein crucial for maintaining embryonic stem cell pluripotency

    OCT4, also known as Octamer-binding transcription factor 4 or POU5F1, is a protein that plays a crucial role in maintaining the self-renewal and pluripotency of embryonic stem cells. It acts as a transcription factor, meaning it helps regulate the expression of genes that are essential for the development and differentiation of cells. This protein is significant in both developmental biology and regenerative medicine, as it helps scientists understand how cells can be reprogrammed to an undifferentiated state.

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    Research 30 of 686

    1. OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases Stem Cell Research & Therapy · 2019 · 57 citations
    2. Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4 Stem cells international · 2015 · 15 citations
    3. Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice Frontiers in Endocrinology · 2020 · 14 citations
    4. ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling Stem Cell Research & Therapy · 2024
    5. Dauricine attenuates Oct4/sonic hedgehog co‐activated stemness and induces reactive oxygen species‐mediated mitochondrial apoptosis via AKT/β‐catenin signaling in human neuroblastoma and glioblastoma stem‐like cells Phytotherapy Research · 2023 · 5 citations
    6. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006 · 344 citations
    7. Human dermal stem cells differentiate into functional epidermal melanocytes Journal of Cell Science · 2010 · 164 citations
    8. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes Development · 2017 · 160 citations
    9. MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2 Stem cells · 2012 · 123 citations
    10. Induced Pluripotent Stem Cells from Human Hair Follicle Mesenchymal Stem Cells Stem Cell Reviews and Reports · 2012 · 64 citations
    11. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    12. Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for <i>in vitro</i> hair follicle cloning PeerJ · 2016 · 18 citations
    13. Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/β‐catenin signaling Cell Biology International · 2014 · 16 citations
    14. Generation of iPS Cells from Human Hair Follice Dermal Papilla Cells Acta naturae · 2014 · 15 citations
    15. Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell-related biomarkers in epithelial skin cells BMC Complementary and Alternative Medicine · 2014 · 13 citations
    16. Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway Frontiers in Cell and Developmental Biology · 2021 · 11 citations
    17. RETRACTED: Tanshinone IIA Pretreatment Renders Free Flaps against Hypoxic Injury through Activating Wnt Signaling and Upregulating Stem Cell-Related Biomarkers International Journal of Molecular Sciences · 2014 · 6 citations
    18. Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche PloS one · 2013 · 6 citations
    19. In vitro identification of a stem cell population from canine hair follicle bulge region 2017 · 5 citations
    20. Establishment and molecular characterization of human dermal mesenchymal-like stem cells derived from human scalp biopsy of androgenetic alopecia patient Stem cell discovery · 2013 · 4 citations
    21. Development and Molecular Characterization of Human Placental Mesenchymal Stem Cells from Human Aborted Fetal Tissue as a Model to Study Mechanism of Spontaneous Abortion Advances in Stem Cells · 2014 · 3 citations
    22. The Role of Box A of<i>HMGB1</i>in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-aging Therapy 2023 · 1 citations
    23. In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion using <i>Ficus religiosa</i> L. and <i>Morus alba</i> L. Journal of Natural Remedies · 2021 · 1 citations
    24. LB1606 Retainability of pluripotency and viability of multilineage-differentiating stress enduring (Muse) cells after repeated cryopreservation. Journal of Investigative Dermatology · 2018 · 1 citations
    25. Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia FASEB BioAdvances · 2025
    26. Exploration of <i>Aloe vera</i>, <i>Centella asiatica</i>, Green Tea, and <i>Pueraria mirifica</i> Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through β-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells Natural Product Communications · 2025
    27. Peer Review #1 of "Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning (v0.1)" 2016
    28. Rancangan televisyen: Menyangga atau menyanggah bahasa dan budaya? PLoS ONE · 2004
    29. Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cells Phytomedicine · 2015 · 21 citations
    30. Immunologic findings in central centrifugal cicatricial alopecia Nasza Dermatologia Online · 2012 · 1 citations