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GlossaryPOU domain

specific protein region that binds DNA to regulate genes

The POU domain is a specific region found in certain proteins that bind to DNA and regulate gene expression. Named after three transcription factors (Pit-1, Oct-1/2, and Unc-86), this domain is crucial for the development and function of various tissues, including the nervous system and the immune system.

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research Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes

74 citations , October 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

The 190-kbp domain contains all human type I hair keratin genes, showing their organization and evolution.

research Tanshinone IIA Pretreatment Protects Free Flaps Against Hypoxic Injury by Upregulating Stem Cell-Related Biomarkers in Epithelial Skin Cells

13 citations , September 2014 in “BMC Complementary and Alternative Medicine”

Tanshinone IIA helps protect skin tissue from low oxygen damage by boosting certain cell markers.

research Identification and Dissection of an Enhancer Controlling Epithelial Gene Expression in Skin

29 citations , February 2001 in “Proceedings of the National Academy of Sciences”

A specific DNA region controls skin cell gene expression by working with certain proteins.

research Transcriptional Regulation Analysis and the Potential Transcription Regulator Site in the Extended KAP6.1 Promoter in Sheep

5 citations , July 2014 in “Molecular Biology Reports”

research OCT4 Maintains Self-Renewal and Reverses Senescence in Human Hair Follicle Mesenchymal Stem Cells Through the Downregulation of p21 by DNA Methyltransferases

57 citations , January 2019 in “Stem Cell Research & Therapy”

OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.

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