Tfap2b Specifies an Embryonic Melanocyte Stem Cell That Retains Adult Multi-Fate Potential

The study identifies Tfap2b and its target genes as key factors in specifying a melanocyte stem cell (McSC) population in zebrafish, which is essential for melanocyte regeneration. These Tfap2b-expressing McSCs, located at the dorsal root ganglia, not only give rise to melanocytes but also have the potential to differentiate into other pigment cell types, such as iridophores and xanthophores. The research demonstrates that Tfap2b is crucial for the identity of McSCs during early development and maintains their ability to produce various pigment cells in adult zebrafish. This discovery provides a deeper understanding of McSC populations beyond those found in hair follicles and could have implications for studies on pigmentation traits and melanoma risk factors.