Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing

    April 2024 in “ Pigment cell & melanoma research ”
    Joseph W. Palmer, Nilesh Kumar, Luye An, Andrew C. White, M. Shahid Mukhtar, Melissa L. Harris
    Image of study
    TLDR Different types of resting melanocyte stem cells have unique characteristics and vary in their potential to become other cells.
    The study used single-cell RNA sequencing to reveal significant molecular heterogeneity within quiescent melanocyte stem cells (qMcSCs) from the telogen skin of adult female C57BL/6J mice. Researchers identified distinct subpopulations based on gene expression patterns, anatomical location, and stem cell potential, using markers like CDH3 and CD34. They mapped 5545 qMcSCs into eight clusters, showing variability in gene expression and biological processes, with some clusters more primed for reactivation and proliferation. The study highlighted the complexity and compartmentalization within the qMcSC pool, providing a comprehensive transcriptomic landscape and suggesting that future research should consider subpopulation composition changes to understand their role in pigmentation maintenance and disease susceptibility.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 8 results

      community Is there any new drug that looks promising ?

      in Research/Science  24 upvotes 9 months ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

      community Please explain this Minoxidil phenomena

      in Minoxidil  58 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

    Related Research

    4 / 4 results