Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells

    January 2020 in “ Nature ”
    Bing Zhang, Sai Ma, Inbal Rachmin … Ya‐Chieh Hsu
    Studysummary Stress can cause hair to turn gray by depleting stem cells.
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    Research cited in this study 9

    1. External Light Activates Hair Follicle Stem Cells Through Eyes Via an ipRGC–SCN–Sympathetic Neural Pathway Proceedings of the National Academy of Sciences of the United States of America · 2018
    2. Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes Cell stem cell · 2017
    3. Identification of Hair Shaft Progenitors That Create a Niche for Hair Pigmentation Genes & development · 2017
    4. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling Cell Reports · 2016
    5. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    6. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    7. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    8. Marie Antoinette Syndrome Archives of Dermatology · 2009
    9. Melanocyte Stem Cell Maintenance and Hair Graying Cell · 2005