Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells

January 2020 in “ Nature ”

Bing Zhang, Sai Ma, Inbal Rachmin, Megan He, Pankaj Baral, Sekyu Choi, William Antônio Gonçalves, Yulia Shwartz, Eva M. Fast, Yiqun Su, Leonard I. Zon, Aviv Regev, Jason D. Buenrostro, Thiago M. Cunha, Isaac M. Chiu, David E. Fisher, Ya‐Chieh Hsu

sympathetic nerves melanocyte stem cells MeSCs hair graying noradrenaline ADRB2 pathway RTX injections gene expression profiling stress-induced sympathetic nerve activity stress-related hair graying

Studysummary Stress can cause hair to turn gray by depleting stem cells.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on nature.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research External Light Activates Hair Follicle Stem Cells Through Eyes Via an ipRGC–SCN–Sympathetic Neural Pathway

61 citations , June 2018 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that light stimulation of intrinsically photosensitive retinal ganglion cells in the eyes can activate hair follicle stem cells through a neural circuit involving the sympathetic nervous system.

research Identification of Hair Shaft Progenitors That Create a Niche for Hair Pigmentation

44 citations , April 2017 in “Genes & development”

This study identified hair shaft progenitors in the matrix that regulate hair growth and pigmentation by creating a niche dependent on stem cell factor, implicating KROX20+ cells in these processes.

research EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling

59 citations , April 2016 in “Cell Reports”

This study demonstrated that EdnrB signaling promotes melanocyte stem cell proliferation and differentiation, enhancing hair and epidermal melanocyte regeneration, especially under conditions of active Wnt signaling.

research Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells

142 citations , February 2016 in “Science”

This review discusses the role of Foxc1 and type XVII collagen in hair follicle stem cell quiescence and aging, identifying mechanisms that relate to hair thinning and hair loss, and reports no new results.

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

This narrative review examines the interactions between skin stem cells and their niches, finding new insights from advancements in genetic and imaging tools but reporting no new experimental results.

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations , June 2011 in “Cell”

This study found that Wnt signaling in the hair follicle is crucial for coordinating the behavior of epithelial and melanocyte stem cells, which drives hair regeneration and melanocyte differentiation in mice.

research Marie Antoinette Syndrome

36 citations , June 2009 in “Archives of Dermatology”

This text is an informational content piece about JAMA Dermatology's website and does not contain any research findings or conclusions.

research Melanocyte Stem Cell Maintenance and Hair Graying

105 citations , April 2005 in “Cell”

This article discusses recent findings on hair graying involving melanocyte stem cell maintenance and key regulatory molecules, and reports no new experimental results.