Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

    Z. Y. Feng, Yi Qin, Guan Jiang
    Studysummary This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ijbs.com →
    Discuss this study in the Community →

    Research cited in this study 71

    1. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    2. Cerebrolysin induces hair repigmentation associated to MART-1/Melan-A reactivation European journal of medical research · 2022
    3. The Physiological and Pharmacological Roles of Prostaglandins in Hair Growth The Korean Journal of Physiology and Pharmacology · 2022
    4. Store-Operated Calcium Channels in Skin Frontiers in Physiology · 2022
    5. Vitamin A in Skin and Hair: An Update Nutrients · 2022
    6. Single-Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying Cell discovery · 2022
    7. Hair Graying Regulators Beyond Hair Follicle Frontiers in physiology · 2022
    8. Adiponectin Negatively Regulates Pigmentation, Wnt/β-Catenin and HGF/c-Met Signaling Within Human Scalp Hair Follicles Ex Vivo Archives of Dermatological Research · 2021
    9. Repigmentation by Combined Narrow-Band Ultraviolet B/Adipose-Derived Stem Cell Transplantation in the Mouse Model: Role of Nrf2/HO-1-Mediated Ca2+ Homeostasis Molecular Medicine Reports · 2021
    10. Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Frontiers in Cell and Developmental Biology · 2021
    11. Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma Exosomes on the Inductivity of Hair Dermal Papilla Cells PubMed · 2021
    12. Discovery of a Transdermally Deliverable Pentapeptide for Activating AdipoR1 to Promote Hair Growth EMBO Molecular Medicine · 2021
    13. Canities Subita After Extreme Trauma Showing Positive Staining for Anti-PD-L1 Antibodies: A New Clue Into Etiopathogenesis? Skin Appendage Disorders · 2021
    14. Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration Tissue Engineering and Regenerative Medicine · 2021
    15. Liposomal Honokiol Promotes Hair Growth Via Activating Wnt3a/β-Catenin Signaling Pathway and Downregulating TGF-β1 in C57BL/6N Mice Biomedicine & Pharmacotherapy · 2021
    16. Updates and new medical treatments for vitiligo (Review) Experimental and Therapeutic Medicine · 2021
    17. Thyroid Hormone Action in Epidermal Development and Homeostasis and Its Implications in the Pathophysiology of the Skin Journal of endocrinological investigation · 2021
    18. Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation Journal of Investigative Dermatology · 2021
    19. Phosphodiesterase Inhibitors and Prostaglandin Analogues in Dermatology: A Comprehensive Review Dermatologic Therapy · 2020
    20. The biology of human hair greying Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2020
    21. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    22. A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia Stem Cells Translational Medicine · 2020
    23. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    24. Hopes and Limits of Adipose-Derived Stem Cells and Mesenchymal Stem Cells in Wound Healing International journal of molecular sciences · 2020
    25. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    26. Extracellular Fraction of Adipose Tissue as an Innovative Regenerative Approach for Vitiligo Treatment Experimental Dermatology · 2019
    27. Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate Adiponectin-Induced Hair Growth Factors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2019
    28. Histopathology of Aging of the Hair Follicle Journal of Cutaneous Pathology · 2019
    29. The Role of Immature and Mature Adipocytes in Hair Cycling Trends in Endocrinology and Metabolism · 2018
    30. Hair Biology Facial Plastic Surgery Clinics of North America · 2018
    31. Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata Stem Cell Research & Therapy · 2018
    32. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    33. Repigmentation and New Hair Growth After Anti-Interleukin-17 Therapy with Secukinumab for Psoriasis JAAD Case Reports · 2018
    34. Emerging Nonmetabolic Functions of Skin Fat Nature Reviews Endocrinology · 2018
    35. Hair Repigmentation Associated With the Use of Brentuximab JAAD Case Reports · 2017
    36. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017
    37. Manifest Hair Repigmentation Associated with Etretinate Therapy The Journal of Dermatology · 2016
    38. Pigmentation of Regenerated Hairs After Wounding Journal of Dermatological Science · 2016
    39. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling Cell Reports · 2016
    40. Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse British journal of dermatology/British journal of dermatology, Supplement · 2016
    41. Localized Hair Repigmentation in a 91-Year-Old Woman JAMA dermatology · 2015
    42. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    43. Thyroxine Differentially Modulates the Peripheral Clock: Lessons from the Human Hair Follicle PLoS ONE · 2015
    44. Cutaneous Adverse Effects of Targeted Therapies Journal of the American Academy of Dermatology · 2015
    45. Repigmentation of Hair Following Adalimumab Therapy Dermatology online journal · 2015
    46. Anti-Graying Effect of the Extract of Pueraria Thunbergiana via Upregulation of cAMP/MITF-M Signaling Pathway Journal of dermatological science · 2014
    47. A Case of Repigmentation and Curling of Hair on Acitretin Therapy Clinical and experimental dermatology · 2013
    48. Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice PLoS ONE · 2013
    49. Dopamine Is a Novel, Direct Inducer of Catagen in Human Scalp Hair Follicles In Vitro British Journal of Dermatology · 2012
    50. Hair Growth-Promoting Effects of Adiponectin In Vitro Journal of Investigative Dermatology · 2012
    51. Hair Repigmentation Associated with the Use of Lenalidomide: Graying May Not Be an Irreversible Process Journal of oncology pharmacy practice · 2012
    52. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    53. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    54. Dietary Isoflavone Increases Insulin-Like Growth Factor-I Production, Thereby Promoting Hair Growth in Mice The Journal of Nutritional Biochemistry · 2011
    55. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    56. Repigmentation of Hair After Latanoprost Therapy Journal of The European Academy of Dermatology and Venereology · 2010
    57. A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation Pigment Cell & Melanoma Research · 2010
    58. The Use of Cyclosporine in Dermatology: Part I Journal of the American Academy of Dermatology · 2010
    59. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008
    60. Neuroendocrinology of Epithelial Hair Follicle Stem Cells Molecular and Cellular Endocrinology · 2008
    61. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    62. Repigmentation of Gray Hair After Thyroid Hormone Treatment Actas dermo-sifiliográficas/Actas dermo-sifiliográficas · 2007
    63. Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage ˜The œFASEB journal · 2006
    64. Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control Experimental Dermatology · 2005
    65. Influence of Prostaglandin F2α and Its Analogues on Hair Regrowth and Follicular Melanogenesis in a Murine Model Experimental dermatology · 2005
    66. Melanocyte Stem Cell Maintenance and Hair Graying Cell · 2005
    67. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    68. Tyrosine Kinase Inhibition and Grey Hair The Lancet · 2003
    69. A Role for p75 Neurotrophin Receptor in the Control of Apoptosis-Driven Hair Follicle Regression The FASEB Journal · 2000
    70. Melanocyte Subpopulation Turnover During the Human Hair Cycle: An Immunohistochemical Study Pigment cell research · 2000
    71. Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998

    Related research 7

    1. Hair Loss (Alopecia or Baldness) 2018
    2. Treatments of Hereditary Hair Loss (Alopecia) 2018
    3. GainmoreTM M: An Oral Supplementation in Men with Androgenic Alopecia for Reduction in Hair Loss and New Hair Growth Europe PMC (PubMed Central) · 2015
    4. Hair Disorders Associated With Anticancer Agents 2013
    5. Effectiveness of the Treatment Plan for Androgenetic Alopecia PubMed · 2007
    6. Treatment of Hair Loss The New England Journal of Medicine · 1999
    7. Nonscarring Hair Loss Disorders Postgraduate Medicine · 1982