The Use of Cyclosporine in Dermatology: Part I

November 2010 in “ Journal of the American Academy of Dermatology ”

Karrie T. Amor, Caitriona Ryan, Alan Menter

cyclosporine psoriasis atopic dermatitis chronic idiopathic urticaria alopecia areata pemphigus vulgaris

Studysummary This article reviews cyclosporine's mechanism, uses, and dosing in dermatology, but reports no new clinical findings, focusing instead on helping dermatologists integrate it safely into their practice. Our plain-language summary of this paper — not a Tressless recommendation.

The document reviewed the use of cyclosporine in dermatology, highlighting its effectiveness in treating various dermatological conditions such as psoriasis, atopic dermatitis, and chronic idiopathic urticaria. It discussed multiple studies, including a meta-analysis involving 579 patients, which confirmed cyclosporine's efficacy in severe psoriasis. The review also noted significant clinical improvements in conditions like alopecia areata and pemphigus vulgaris. Despite its benefits, the document emphasized the importance of monitoring for potential side effects and optimizing dosages to ensure a balance between efficacy and safety.

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Research cited in this study

4 / 4 results

research Alopecia Areata Presenting in Two Kidney-Pancreas Transplant Recipients Taking Cyclosporine

23 citations , October 2005 in “Journal of The American Academy of Dermatology”

This report describes the unexpected development of alopecia areata in kidney-pancreas transplant recipients undergoing cyclosporine-based immunosuppressive therapy, suggesting a complex relationship between the treatment and disease.

research Alopecia Areata in Down Syndrome: A Clinical Evaluation

22 citations , May 2005 in “Journal of the European Academy of Dermatology and Venereology”

This article discusses alopecia areata in individuals with Down syndrome and reports no new clinical findings.

research Guidelines for the Management of Alopecia Areata

182 citations , October 2003 in “British Journal of Dermatology”

These guidelines for alopecia areata management, prepared by the British Association of Dermatologists, provide evidence-based treatment recommendations and insights into the condition's epidemiology, diagnosis, and investigation.

research Partial Response of Severe Alopecia Areata to Cyclosporine A

30 citations , January 1999 in “Dermatology”

This study found that cyclosporine A may lead to partial hair regrowth in 50% of patients with severe alopecia areata who do not respond to standard treatments.