TLDR Cyclosporine is effective for skin conditions but has declined in use due to toxicity concerns.
The document reviewed the use of cyclosporine in dermatology, highlighting its effectiveness in treating various dermatological conditions such as psoriasis, atopic dermatitis, and chronic idiopathic urticaria. It discussed multiple studies, including a meta-analysis involving 579 patients, which confirmed cyclosporine's efficacy in severe psoriasis. The review also noted significant clinical improvements in conditions like alopecia areata and pemphigus vulgaris. Despite its benefits, the document emphasized the importance of monitoring for potential side effects and optimizing dosages to ensure a balance between efficacy and safety.
23 citations,
October 2005 in “Journal of The American Academy of Dermatology” Two transplant patients on cyclosporine unexpectedly developed hair loss.
22 citations,
May 2005 in “Journal of the European Academy of Dermatology and Venereology” People with Down syndrome are more likely to have alopecia areata and need regular skin check-ups.
182 citations,
October 2003 in “British Journal of Dermatology” The 2003 guidelines suggest that while some treatments can regrow hair in alopecia areata, none alter the disease's progression, and wigs may be the best option for extensive hair loss.
30 citations,
January 1999 in “Dermatology” Cyclosporine A can help some people with severe alopecia areata regrow hair.
January 2009 in “Springer eBooks” The document concludes that treating skin conditions should include psychological care and a multidisciplinary approach is essential for effective management.
22 citations,
January 2012 in “Mediators of inflammation” Nonantibiotic macrolides show promise for treating various inflammatory skin conditions.
2 citations,
January 2014 in “Springer eBooks” The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
59 citations,
June 2022 in “Frontiers in medicine” There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
4 citations,
January 2014 in “Indian journal of paediatric dermatology” Methotrexate is effective and well-tolerated in children for certain skin conditions but requires careful monitoring.
