Clinical Application of Nonantibiotic Macrolides for Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases

January 2012 in “ Mediators of inflammation ”

Carmen Rodríguez-Cerdeira, Elena Sánchez-Blanco, Alberto Molares-Vila

pimecrolimus tacrolimus calcineurin cytokine atopic dermatitis psoriasis oral lichen planus vitiligo Behçet's disease chronic autoimmune urticaria alopecia areata CSY0073 EM900 EM911 Elidel Protopic

Studysummary This review discusses the potential benefits of nonantibiotic macrolides for treating inflammatory skin disorders and reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discussed the development and clinical application of nonantibiotic macrolides, such as pimecrolimus and tacrolimus, for treating inflammatory skin diseases. These macrolides exhibited anti-inflammatory properties by inhibiting calcineurin and reducing cytokine production, which opened new treatment avenues with minimal side effects. Pimecrolimus showed efficacy in conditions like atopic dermatitis, psoriasis, and oral lichen planus, while tacrolimus was beneficial for vitiligo and Behçet's disease. However, pimecrolimus was less effective for chronic autoimmune urticaria and alopecia areata. New macrolides like CSY0073, EM900, and EM911 demonstrated potential in preclinical studies, indicating promising future applications.

View this study on downloads.hindawi.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Comparison of Treatment with Clobetasol Propionate 0.05% and Topical Pimecrolimus 1% in Alopecia Areata

13 citations , July 2011 in “Journal of Dermatological Treatment”

This study found that topical pimecrolimus is as effective as clobetasol propionate for treating alopecia areata, with better tolerability in terms of side effects.

Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide, and Tacrolimus Ointment in Management of Localized Alopecia Areata

research Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide, and Tacrolimus Ointment in Management of Localized Alopecia Areata

48 citations , January 2011 in “International journal of trichology”

This study found that intralesional triamcinolone acetonide was most effective for hair regrowth in localized alopecia areata, with betamethasone valerate foam also being beneficial, while tacrolimus ointment showed no significant effect.

research Frontal Fibrosing Alopecia: Treatment with Oral Dutasteride and Topical Pimecrolimus

69 citations , August 2008 in “Journal of The European Academy of Dermatology and Venereology”

Oral dutasteride and topical pimecrolimus can safely and effectively treat Frontal Fibrosing Alopecia, leading to significant hair regrowth.

research Tacrolimus in Dermatology

35 citations , August 2001 in “Journal of Cutaneous Medicine and Surgery”

This paper reviews the use of tacrolimus for various conditions, noting its effectiveness in treating certain skin disorders but highlighting that some findings remain anecdotal due to limited case numbers.