TLDR Nonantibiotic macrolides show promise for treating various inflammatory skin conditions.
The document discussed the development and clinical application of nonantibiotic macrolides, such as pimecrolimus and tacrolimus, for treating inflammatory skin diseases. These macrolides exhibited anti-inflammatory properties by inhibiting calcineurin and reducing cytokine production, which opened new treatment avenues with minimal side effects. Pimecrolimus showed efficacy in conditions like atopic dermatitis, psoriasis, and oral lichen planus, while tacrolimus was beneficial for vitiligo and Behçet's disease. However, pimecrolimus was less effective for chronic autoimmune urticaria and alopecia areata. New macrolides like CSY0073, EM900, and EM911 demonstrated potential in preclinical studies, indicating promising future applications.
13 citations,
July 2011 in “Journal of Dermatological Treatment” Clobetasol and pimecrolimus are similarly effective for alopecia areata, but pimecrolimus has fewer side effects and is preferred for long-term use.
48 citations,
January 2011 in “International journal of trichology” Intralesional triamcinolone acetonide is the most effective treatment for localized alopecia areata.
69 citations,
August 2008 in “Journal of The European Academy of Dermatology and Venereology” Oral dutasteride and topical pimecrolimus can safely and effectively treat Frontal Fibrosing Alopecia, leading to significant hair regrowth.
35 citations,
August 2001 in “Journal of Cutaneous Medicine and Surgery” Tacrolimus is effective for various skin conditions with fewer side effects than cyclosporine.
104 citations,
August 2008 in “Clinics in Dermatology” Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.
January 2017 in “Springer eBooks” The document explains various skin conditions and their treatments.
January 2016 in “Kafkas Journal of Medical Sciences” Turkish pregnant women commonly experienced skin issues like itching and acne, and doctors mainly used topical treatments due to safety concerns during pregnancy.
9 citations,
February 2011 in “Biologics: Targets & Therapy” Topical calcineurin inhibitors, especially 0.1% tacrolimus ointment, are effective and well-tolerated for treating cutaneous lupus erythematosus but require more research for standard treatment guidelines.
59 citations,
June 2022 in “Frontiers in medicine” There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
