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    Glossary Calcineurin

    enzyme crucial for activating T-cells in immune response

    Calcineurin is an enzyme that plays a crucial role in activating T-cells, which are essential for the immune response. It is involved in various cellular processes, including the regulation of hair growth, and is a target for certain immunosuppressive drugs used to treat conditions like alopecia areata, where the immune system attacks hair follicles.

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    Research 10 of 786

    1. The Many Faces of Calcineurin Inhibitor Toxicity—What the FK? Advances in chronic kidney disease · 2020 · 97 citations
    2. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes American Journal of Physiology-cell Physiology · 2003 · 57 citations
    3. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation Genes & Development · 2014 · 40 citations
    4. Endocrine effects of long-term calcineurin inhibitor use in solid organ transplant recipients European Journal of Endocrinology · 2025 · 7 citations
    5. 1379 Cyclosporin A suppresses TGF-β2 expression via calcineurin/NFAT pathway in human dermal papilla cells Journal of Investigative Dermatology · 2023
    6. Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma International journal of dermatology and venereology · 2019
    7. Calcineurin-based immunosuppression in renal transplantation : focus on efficacy, the role of steroids, and the cardiovascular risk 2006
    8. Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus Biologics: Targets & Therapy · 2011 · 9 citations
    9. Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors? International Journal of Dermatology · 2023 · 1 citations
    10. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization EMBO journal · 2018 · 344 citations
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