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GlossaryCalcineurin

enzyme crucial for activating T-cells in immune response

Calcineurin is an enzyme that plays a crucial role in activating T-cells, which are essential for the immune response. It is involved in various cellular processes, including the regulation of hair growth, and is a target for certain immunosuppressive drugs used to treat conditions like alopecia areata, where the immune system attacks hair follicles.

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research The Many Faces of Calcineurin Inhibitor Toxicity—What the FK?

97 citations, January 2020 in “Advances in chronic kidney disease”

Calcineurin inhibitors, used in kidney transplants, can cause a wide range of side effects including kidney damage and other health issues.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations, June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

research Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation

40 citations, April 2014 in “Genes & Development”

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

research Cyclosporin A Suppresses TGF-Beta2 Expression Via Calcineurin/NFAT Pathway in Human Dermal Papilla Cells

April 2023 in “Journal of Investigative Dermatology”

Cyclosporin A, a drug, reduces TGF-β2 expression in skin cells, potentially causing excessive hair growth through a process involving the calcineurin/NFAT pathway.

research Calcineurin-Based Immunosuppression in Renal Transplantation: Focus on Efficacy, the Role of Steroids, and Cardiovascular Risk

August 2021

Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

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