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Glossary Topical Calcineurin Inhibitors

medications applied to skin to reduce immune responses

Topical Calcineurin Inhibitors (TCIs) are medications applied to the skin to reduce inflammation and immune responses. They work by blocking the activity of calcineurin, a protein that activates T-cells in the immune system, making them useful in treating conditions like eczema and vitiligo. Unlike corticosteroids, TCIs do not cause skin thinning, making them a safer long-term option for sensitive areas.

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Research

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research Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus

9 citations , February 2011 in “Biologics: Targets & Therapy”

This review discusses topical calcineurin inhibitors for cutaneous lupus erythematosus and reports no new clinical findings; the authors emphasize the need for more comparative studies with corticosteroids.

Scalp Atrophy Secondary to Steroid Use in Patients With Scarring Alopecia: Are Topical Steroids Superior to Topical Calcineurin Inhibitors?

research Scalp atrophy secondary to steroid use in patients with scarring alopecia: are topical steroids superior to topical calcineurin inhibitors?

1 citations , November 2023 in “International Journal of Dermatology”

This commentary discusses whether topical steroids or topical calcineurin inhibitors are better for treating scalp atrophy caused by steroid use in patients with scarring alopecia, but specific results or conclusions are not provided.

research Resolution of Discoid Lupus Alopecia With Systemic Hydroxychloroquine and Topical Pimecrolimus Combination Therapy

June 2024 in “Cureus”

In this case study, a 46-year-old woman with localized discoid lupus erythematosus on her scalp showed significant improvement with a combination of oral hydroxychloroquine and topical pimecrolimus, despite limited success with previous treatments.

research Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

19 citations , May 2021 in “Clinical, Cosmetic and Investigational Dermatology”

This review discusses the progress in research on topical formulations for treating alopecia, highlighting potential advantages of advanced formulation technologies but reporting no new clinical results.

research Common Topical Medications

October 2018 in “Springer eBooks”

The document concludes that various topical medications are effective for skin conditions but often cause skin irritation as a side effect.

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community Topical - Lantoprost .01%, MIN 10% DUT .05%, Hydrocortisone 1% Progrestron .025%

in Treatment 6 upvotes 1 year ago

A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.

community I had claude create a protocol only using fda approved drugs.

4 upvotes 8 months ago

A new hair loss protocol using FDA-approved topical treatments targets eight pathways, potentially improving results by 60-75% compared to the standard 40-50% from oral minoxidil and finasteride. The protocol includes minoxidil, finasteride, tacrolimus, cetirizine, bimatoprost, lithium gluconate, losartan, melatonin, NAC, caffeine, and tretinoin, with a monthly cost of $35-50 in Mexico and $80-150 in the US.

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