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    GlossaryTopical Calcineurin Inhibitors

    medications applied to skin to reduce immune responses

    Topical Calcineurin Inhibitors (TCIs) are medications applied to the skin to reduce inflammation and immune responses. They work by blocking the activity of calcineurin, a protein that activates T-cells in the immune system, making them useful in treating conditions like eczema and vitiligo. Unlike corticosteroids, TCIs do not cause skin thinning, making them a safer long-term option for sensitive areas.

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      a topical anti-androgen with less systemic involvement

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      powerful topical and oral anti-androgen used mostly by women

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn RU58841

      a potent but unapproved and potentially problematic topical anti-androgen

      learn Melatonin

      hormone commonly taken for sleep aid has some topical benefits for hair

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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Topical fin 0.025%, min 5% - 2,5 months progress

      in Finasteride/Dutasteride  9 upvotes 3 days ago
      The user started using topical finasteride 0.025% and minoxidil 5% twice daily, seeing initial improvement but later experiencing shedding and scalp pain. They are considering increasing the finasteride dose to 0.05% while using keto shampoo and dermarolling, and are debating the effectiveness of low versus standard doses of finasteride.

      community Topical - Dosage help (0.3% FIN per mL?)

      in Finasteride/Dutasteride  1 upvotes 5 days ago
      The user is considering starting a topical treatment for hair loss, using a spray containing 0.3% finasteride, 5% minoxidil, and 0.01% tretinoin. They are questioning the dosage and considering reducing the application to achieve 0.15% finasteride and 5% minoxidil.