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    Glossary Topical Calcineurin Inhibitors

    medications applied to skin to reduce immune responses

    Topical Calcineurin Inhibitors (TCIs) are medications applied to the skin to reduce inflammation and immune responses. They work by blocking the activity of calcineurin, a protein that activates T-cells in the immune system, making them useful in treating conditions like eczema and vitiligo. Unlike corticosteroids, TCIs do not cause skin thinning, making them a safer long-term option for sensitive areas.

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    1. Fluridil Topical anti-androgen sold as a cosmetic lotion
    2. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    3. Pyrilutamide Experimental topical anti-androgen, also known as KX-826
    4. RU58841 Experimental topical anti-androgen sold as a research chemical
    5. GT20029 Experimental topical drug designed to break down androgen receptors