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Glossary Topical Gel

semi-solid substance applied to skin or scalp for local treatment

A topical gel is a semi-solid substance applied directly to the skin or scalp to deliver medication or active ingredients locally. It is designed to be absorbed through the skin, providing targeted treatment for conditions such as inflammation, infections, or hair loss, without affecting the rest of the body.

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Research

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research Phase I/II randomized bilateral half-head comparison of topical bexarotene 1% gel for alopecia areata

44 citations , October 2009 in “Journal of the American Academy of Dermatology”

This study reported that 1% bexarotene gel was well tolerated and possibly effective for inducing partial hair regrowth in alopecia areata, but more rigorous trials are needed to confirm its efficacy.

research Formulation and Evaluation of Finasteride Loaded Nanoparticles Based Topical Gel for the Management of drogenetic Alopecia

July 2026 in “Journal of Drug Delivery and Therapeutics”

This study evaluated Finasteride-loaded nanostructured lipid carriers for topical use in treating androgenetic alopecia and found that these carriers offer sustained drug release and may reduce systemic side effects compared to oral administration.

research Developing Topical Gel Formulation of Erandakarkati (Carica papaya Linn.) Latex for Managing Indralupta: A Preliminary Study

May 2025 in “International Research Journal of Ayurveda & Yoga”

This pilot study found that using a topical Carica papaya latex gel for 28 days reduced hair fall and promoted hair regrowth in individuals with Indralupta, although the bald patch size did not significantly change, indicating the potential need for longer treatment or additional interventions.

research Dutasteride Topical Gel Containing Herbal Extract for Male Pattern Baldness

December 2024 in “International Journal of Drug Delivery Technology”

In this study, researchers developed and evaluated a topical dutasteride gel for treating male pattern baldness, finding that a formulation with 10% garlic extract showed the most promising results in promoting faster hair growth compared to other formulations tested.

research Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-loaded Nano Lipidic Carriers-infused Topical Gel - In vitro and In vivo Skin Permeation Studies

February 2024 in “International journal of pharmaceutical sciences and nanotechnology”

In this article, researchers explored the potential of lipidic nanocarriers to enhance the delivery and effectiveness of finasteride in a topical gel form for androgenic alopecia, aiming to improve treatment options and reduce systemic adverse effects.

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Community Join

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community Topical Finasteride Gel 1% after 4 months — problems

in Finasteride 156 upvotes 11 months ago

The user experienced hair thinning due to a testosterone spike and used a minoxidil solution and topical finasteride gel. After four months, the gel caused side effects without improving hair thinning, leading to questions about continuing or adjusting the treatment.

community GFM Gel - High concentration topical gel of Mimicking Growth Factors (GFm), a complex of polypeptides that mimic the action of endogenous growth factors and promote physiological hair regrowth. Helps strengthen the hair bulb and redensify the hair.

6 upvotes 1 year ago

The conversation discusses using GFM Gel, a topical gel with polypeptides that mimic growth factors to promote hair regrowth and strengthen hair. It also mentions treatments like Minoxidil, finasteride, and RU58841 for hair loss.

community Attempting PP-405 topical gel reformulation

20 upvotes 2 weeks ago

A user is attempting to reformulate a topical gel using PP-405 for hair loss, aiming to enhance its effectiveness with additional compounds. They discuss the potential of PP-405 compared to other treatments like Minoxidil and GT20029, and emphasize the importance of proper formulation for efficacy.

community Can I make Topical Dutasteride by mixing Dut gel capsules with castor oil?

4 upvotes 2 years ago

The user is considering mixing 15mg of dutasteride with 60ml of castor oil for mesotherapy (micro-needling) to treat hair loss. They are asking if this method is viable.

community Is Maximustribe All-in-One Topical Gel worth it? Has anyone here tried it and got good results?

in Basic Questions 38 upvotes 1 month ago

The conversation is about whether the Maximustribe All-in-One Topical Gel, containing dutasteride, spironolactone, tretinoin, minoxidil, fexofenadine, melatonin, and caffeine, is worth the price of $178.72 for three months. Users are discussing its effectiveness for hair loss treatment.

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Learn

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learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

Can PP405 help bald patches caused by stress? PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.
Can applying a mask with PP405 directly to thinning areas give your scalp the push it needs? No PP405 mask exists to test: PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, it is not an anti-DHT ingredient, and it is not on sale. Its registered Phase 2 trial (NCT06393452) measured safety, not regrowth, and a rinse-out mask is in any case the wrong format for reaching the follicle.
Is PP405 a peptide that protects follicles from DHT? PP405 is not a peptide and does not block DHT: it is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, aimed at waking dormant follicles. Its registered Phase 2 trial (NCT06393452) measured safety and tolerability in 78 adults with pattern hair loss; it is not approved and not for sale.

learn Estradiol

Estrogen hormone, prescribed in tablet, patch and gel forms

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

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Experts

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SMP Specialist
David Gellei
Melbourne, VIC, Australia

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David Gellei