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GlossaryTopical Calcineurin Inhibitors

medications applied to skin to reduce immune responses

Topical Calcineurin Inhibitors (TCIs) are medications applied to the skin to reduce inflammation and immune responses. They work by blocking the activity of calcineurin, a protein that activates T-cells in the immune system, making them useful in treating conditions like eczema and vitiligo. Unlike corticosteroids, TCIs do not cause skin thinning, making them a safer long-term option for sensitive areas.

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community Topical aldactone for men’s hair and muscle effects

in Treatments 18 upvotes 4 days ago

Topical aldactone is discussed for its effects on men's hair and muscles. The conversation explores its potential benefits and side effects compared to other treatments like Minoxidil, finasteride, and RU58841.

community Topical FIN/MIN 0.03% / 6% (Day 2) HAIR IS CURRENTLY WET & PARTED. As you can see my main issues are the crown / mid scalp area. Can’t wait until I start seeing results!

in Finasteride/Dutasteride 11 upvotes 5 days ago

The conversation discusses using topical finasteride and minoxidil for hair loss, focusing on the crown and mid-scalp areas. The user is optimistic about seeing results in 3 to 6 months.

community Topical fin formulation question

in Finasteride 91 upvotes 1 week ago

A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

community Topical finasteride carrier/vehicle

in Finasteride 135 upvotes 3 weeks ago

The user is considering making a homemade topical finasteride solution using an ethanol-based carrier. They are inquiring if a solution containing partially denatured ethyl alcohol and benzalkonium chloride is suitable.

community Why not use hair system instead of Topical Hassle

in Hair Systems 18 upvotes 1 month ago

Topical treatments like minoxidil and finasteride are preferred for hair loss due to ease of use and natural appearance. Hair systems are considered high-maintenance and less genuine.

community 4 months topical minoxidil + 2 months finasteride

in Minoxidil 132 upvotes 1 month ago

Topical minoxidil and oral finasteride are effectively promoting hair growth with minimal side effects, such as no impact on sex drive. Users report positive results and reduced hair shedding, with some using a combination of topical foam containing both minoxidil and finasteride.

community Why isnt topical fin talked about more?

in Chat 44 upvotes 1 month ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

community Topical Minoxidil Hyperresponder

in Minoxidil 9 upvotes 1 month ago

Minoxidil helped regrow hair from NW3 to NW2 in 5 months despite initial shedding, with additional use of Vitamin D3/K2 on the scalp. Users discuss patience during shedding and the importance of continuing treatments like Minoxidil and Finasteride.

community Topical dutasteride valid success stories

in Finasteride/Dutasteride 1 upvotes 2 months ago

Topical dutasteride may not significantly reduce hair loss and could potentially increase testosterone, leading to further hair loss. Users report side effects like mood changes, sleep issues, and severe side effects, with no significant progress in hair regrowth.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 13 upvotes 2 months ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community Topical Exosomes w derma roller??

in Research/Science 1 upvotes 2 months ago

The conversation discusses using topical exosomes with a derma roller for hair loss. Users also mention minoxidil for treatment.

community Topical min/fin for 8 months. Still seeing continuous miniaturisation

in General 50 upvotes 2 months ago

After 8 months of using topical finasteride, hair miniaturization continues, raising concerns about its effectiveness. Microneedling is suggested as a possible complementary treatment.

community Why a lot of people seems to hate on topical fin even though it suppresses more scalp dht?

in Chat 20 upvotes 2 months ago

Topical finasteride may reduce more scalp DHT but is seen as inconsistent and messy compared to oral finasteride. Users report mixed results with both forms, with some preferring oral for its convenience and consistent dosing, while others find topical effective but harder to apply.

community Topical min users, how long does your evening routine take?

in Chat 8 upvotes 3 months ago

Applying Minoxidil takes users between 10 seconds to 20 minutes, with most finding quicker methods more efficient. Techniques vary from using foam, liquid, or spray, with some users recommending buzz cuts for easier application.

community Topical Dutasteride & Microneedling Works

in Finasteride/Dutasteride 6 upvotes 3 months ago

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.

community How to use topical fin and user experiences with it

in General 104 upvotes 3 months ago

Topical finasteride and minoxidil, combined with microneedling, are recommended for treating thinning hair areas, with 1-2 sprays daily being effective and having fewer side effects than oral finasteride. Starting microneedling at 1.0mm is advised for effectiveness while minimizing invasiveness.

community Topical bicalutamide vs ru58841

in Female 1 upvotes 3 months ago

A user is seeking advice on making a topical bicalutamide solution as an alternative to RU58841 for hair loss, while already using dutasteride and minoxidil. They are considering crushing bicalutamide pills and adding them to their minoxidil.

community Has anyone used topical estrogen or estradiol for hair loss and how effective was it?

in Treatment 1 upvotes 3 months ago

Topical estrogen or estradiol for hair loss is being discussed for its effectiveness compared to finasteride. Users are sharing their experiences and opinions on its potential benefits.

community Topical Minoxidil foam + Finasteride

in Finasteride/Dutasteride 1 upvotes 3 months ago

The conversation discusses using minoxidil foam as a solvent for topical finasteride. Ingredients of minoxidil foam include butane, cetyl alcohol, glycerin, and purified water.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI

in Finasteride/Dutasteride 26 upvotes 4 months ago

The conversation discusses the effectiveness and skepticism around topical dutasteride for hair loss, with mentions of combining it with other treatments like minoxidil and oral medications. Some users doubt its efficacy due to lack of independent studies and potential conflicts of interest.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 450 upvotes 4 months ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

community Topical minoxidil and salicylic acid

in Minoxidil 4 upvotes 4 months ago

The user has been using finasteride for 6 months with decent results and recently added topical minoxidil. They are concerned that salicylic acid in their skincare products might reduce minoxidil's effectiveness.

community Topical Finasteride Selection

in Finasteride/Dutasteride 1 upvotes 4 months ago

A user is seeking advice on choosing the right topical finasteride for hair loss, considering different formats (spray, gel, aqueous solution) and brands (Xyon, Ro, Keeps, Hims Rx Hair Loss Serum, Happy Head Topical Rx Serum). They are also concerned about the optimal strength to minimize side effects while using it with topical minoxidil.

community Topical finasteride & minoxidil

in Finasteride/Dutasteride 1 upvotes 4 months ago

A 20-year-old is using a topical solution with finasteride, minoxidil, and tretinoin for hair thinning. They seek advice on application, duration, and potential results.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 5 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Topical Dutasteride 0.025% 2ml once a week

in Treatment 8 upvotes 5 months ago

A user discusses using topical dutasteride 0.025% once a week for hair maintenance, alongside fortified minoxidil, RU58841, and Reviv Hair Serum. They seek feedback on the effectiveness of this regimen.

community Worth giving topical fin a chance if oral gave strong depression? 23M

in Finasteride/Dutasteride 1 upvotes 5 months ago

A 23-year-old experienced severe depression and suicidal thoughts from oral finasteride and is considering trying topical finasteride but is worried about similar side effects. They are currently using RU58841 and Minoxidil and are seeking advice on the lowest effective dose of topical finasteride.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 82 upvotes 5 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community Topical anti-androgen availability in Australia

in Product 5 months ago

Availability of topical anti-androgens, especially RU58841, in Australia. Issues with customs seizures and lack of credible local sources.

community Topical Spironolactone 5% effectiveness

in Product 2 upvotes 5 months ago

Topical spironolactone 5% is being discussed for its effectiveness in treating hair loss, specifically receding temples. The user is inquiring if it works similarly to finasteride as a testosterone blocker.