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Glossary Topical Calcineurin Inhibitors

medications applied to skin to reduce immune responses

Topical Calcineurin Inhibitors (TCIs) are medications applied to the skin to reduce inflammation and immune responses. They work by blocking the activity of calcineurin, a protein that activates T-cells in the immune system, making them useful in treating conditions like eczema and vitiligo. Unlike corticosteroids, TCIs do not cause skin thinning, making them a safer long-term option for sensitive areas.

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community Topical - Lantoprost .01%, MIN 10% DUT .05%, Hydrocortisone 1% Progrestron .025%

in Treatment 6 upvotes 1 year ago

A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.

community I had claude create a protocol only using fda approved drugs.

4 upvotes 8 months ago

A new hair loss protocol using FDA-approved topical treatments targets eight pathways, potentially improving results by 60-75% compared to the standard 40-50% from oral minoxidil and finasteride. The protocol includes minoxidil, finasteride, tacrolimus, cetirizine, bimatoprost, lithium gluconate, losartan, melatonin, NAC, caffeine, and tretinoin, with a monthly cost of $35-50 in Mexico and $80-150 in the US.

community Are topical anti-androgens (spironolactone, clascoterone, RU58841) sold/available in Egypt?

2 upvotes 1 day ago

Topical anti-androgens like spironolactone, clascoterone, and RU58841 are not readily available in Egypt, with inconsistent availability through online platforms. Minoxidil is commonly found in local pharmacies, while dutasteride is available as "Avodart" but is expensive.

community Topical 7% Min and 0.005% Fin. Should I consider tretinoin, cetirizine, melatonin, caffeine?

1 day ago

The user resumed using topical 5% minoxidil after experiencing hair shedding and is now considering adding topical 7% minoxidil with 0.005% finasteride. They are seeking advice on whether to add tretinoin, cetirizine, melatonin, or caffeine to their regimen, with concerns about tretinoin's sensitivity to sunlight.

community Does topical Finasteride look milky?

1 upvotes 2 days ago

Topical finasteride should not appear milky; it seems the pharmacy may have used crushed pills instead of pure powder. It's advised to return the product and seek a better formulation from another pharmacy for optimal results.

community topical 0.02% dutasteride / dutasteride mesotheraphy

1 upvotes 4 days ago

The conversation is about using topical 0.02% dutasteride and dutasteride mesotherapy for aggressive hair loss, with the user avoiding finasteride due to potential side effects. Another user shares that they experienced side effects with topical dutasteride.

community How systematic would topical dutasteride go?

3 upvotes 6 days ago

Topical dutasteride's effectiveness and systemic absorption are debated, with mixed anecdotal evidence on side effects and regrowth. Some users report systemic effects, while others believe the molecules are too large to penetrate the skin.

community Has anyone tried topical ghk cu with good results?

1 week ago

Topical GHK-CU is reported to improve hair thickness and skin appearance, with some users noting fuller hair and reduced wrinkles. Injectable GHK-CU has mixed reviews, with some seeing benefits and others noticing little change.

community Topical Minxodil stoped working- switching to oral?

1 upvotes 1 week ago

The user experienced reduced effectiveness of topical Minoxidil after three years and is considering switching to oral Minoxidil, while also using finasteride for six months without significant hair regrowth. Suggestions include continuing finasteride for longer, considering oral Minoxidil, or switching to dutasteride for better results.

community Topical Finasteride dose doubts

1 week ago

A user is considering using a topical compound of 0.25% finasteride and 5% minoxidil for hair loss, concerned about side effects experienced with oral finasteride. Other users suggest starting with a lower concentration and possibly diluting the solution to minimize side effects.

community Topical Minoxidil causes this face puffiness?

32 upvotes 1 week ago

A user is concerned about facial puffiness potentially caused by minoxidil, but others suggest it might be due to aging, lighting, or water retention. The user has been using topical minoxidil for 8 months and recently started oral minoxidil, noticing changes in facial appearance.

community Topical finasteride - Can anyone here share their results?

4 upvotes 1 week ago

Topical finasteride combined with oral minoxidil is used by some for hair loss, with mixed results; some users report success while others find it difficult to apply. Alternatives like oral finasteride and microneedling are also considered, with some users experiencing hair stabilization and new growth.

community Question about topical finasteride dosage

1 upvotes 1 week ago

Topical finasteride is being used to minimize side effects experienced with oral finasteride. Users suggest diluting the topical solution to reduce potential side effects, as the current concentration is considered too high.

community TOPICAL dut vs. ORAL fin: more effective?

4 upvotes 2 weeks ago

Switching from oral finasteride to topical dutasteride for hair loss, with mixed experiences reported; some users found oral treatments more effective. Combining treatments like dutasteride and minoxidil was also suggested for better results.

community Topical min safe for someone on beta blockers?

2 upvotes 2 weeks ago

A 21-year-old with mild tachycardia on beta blockers is considering using topical 5% minoxidil for hair loss. They are seeking advice on its safety given their condition.

community Topical Fin & DUT at the same time?

1 upvotes 2 weeks ago

The conversation discusses using a combination of topical treatments for hair loss, including Minoxidil, Finasteride, Dutasteride, and micro-needling. The users consider switching between different topical blends to enhance results, despite official advice suggesting one 5AR inhibitor is sufficient.

community Topical Dutasteride 0.05% With Trichosol In Europe

5 upvotes 3 weeks ago

A user from Ireland is seeking topical dutasteride with trichosol, which is unavailable in Ireland, and is looking for European pharmacies that can provide it. Recommendations include pharmacies in Switzerland, Italy, Belgium, and Bucharest, with mixed reviews about Farmacia Parati in Italy.

community TOPICAL Finasteride vs TOPICAL Dutasteride.

6 upvotes 3 weeks ago

Topical finasteride is generally considered more effective than topical dutasteride due to better scalp absorption. Users suggest combining topical finasteride with minoxidil and tretinoin while reducing oral dutasteride dosage to minimize side effects.

community Do not recommend topical finasteride after two years.

117 upvotes 3 weeks ago

Topical finasteride was ineffective for some users, leading to hair loss, while others found it beneficial. Alternatives like oral finasteride, dutasteride, minoxidil, and combinations with tretinoin and keto shampoo were suggested.

community Topical Minoxidil Sensitivity Test?

1 upvotes 1 month ago

The user is considering starting hair loss treatment with topical Minoxidil but is concerned about its efficacy due to enzyme levels and is seeking a Minoxidil sensitivity test. They plan to switch to oral Minoxidil if necessary and consider using clascoterone in the future, with a suggestion to add microneedling to improve results.

community Topical Min 7% and Fin .07%, only a couple weeks in

in Is this regrowth? 7 upvotes 1 month ago

The user is using topical Minoxidil 7% and Finasteride 0.07% for hair regrowth and is concerned about visible changes and what to expect. Responses suggest it's too early to see results, shedding may occur, and consistency is important.

community Topical Finasteride and Minoxidil results after 1 year

33 upvotes 1 month ago

A 25-year-old shared progress pictures after using 0.3% topical finasteride and 8% minoxidil for a year, showing improved hairline and positive feedback. They use a telehealth solution from Happy Head and CVS foam minoxidil.

community Topical min + topical fin + dermastamp weekly 1mm, about 9 weeks progress, i think it's going great so far

31 upvotes 1 month ago

The user reported positive progress in hair regrowth using a combination of topical minoxidil, homemade topical finasteride, weekly dermastamping, and ketoconazole shampoo over nine weeks. They switched from oral to topical finasteride due to side effects and noted that the long hair seen is from a hair transplant.

community Topical minoxidil can still kill cats even when the owner is “careful.”

in Minoxidil 259 upvotes 1 month ago

Topical minoxidil can be dangerous to cats, even with accidental exposure, and users should be cautious to prevent poisoning. Proper precautions, like washing hands and preventing cats from licking treated areas, are essential to minimize risk.

community Topical fin min - 2 months regrowth

69 upvotes 1 month ago

A 33-year-old man using topical finasteride 0.25%, minoxidil 5%, and Nizoral for hair regrowth reports noticeable progress after 50 days, with plans to add microneedling. He experienced initial side effects with finasteride, which later subsided, and hopes to restore his crown for a potential hair transplant.

community Topical finasteride vs RU58841 vs KX826

1 upvotes 1 month ago

The user is considering switching from topical finasteride to RU58841 or KX826 to reduce side effects but decides to stick with finasteride for now. Users discuss the effectiveness and risks of RU58841 and KX826, with finasteride being considered the most reliable option.

community Is it possible for topical finasteride to be more effective than dutasteride for some people?

in Finasteride/Dutasteride 5 upvotes 1 month ago

Topical finasteride may be more effective than dutasteride for some individuals, with some users reporting better results with finasteride. Combining finasteride and dutasteride in a topical formula is questioned for its effectiveness.

community Topical Finasteride in DMSO works?

1 month ago

Topical finasteride in DMSO is discussed as a potential treatment for hair loss. Users share experiences and opinions on its effectiveness.

community Where to find topical dutasteride in the US? Everywhere I look is really expensive

in Finasteride/Dutasteride 4 upvotes 1 month ago

Topical dutasteride is expensive in the US, with users discussing alternatives like oral dutasteride, which some find more effective. Some users consider making their own topical solutions using raw powder to save costs.

community Topical Anti Androgens detailed thread

6 upvotes 1 month ago

Users discuss the effectiveness of topical anti-androgens like RU58841, Pyri (KX826), and CB for hair loss. Some report maintenance and regrowth with Pyri, while others find limited success with RU58841 and switch to combinations like finasteride and minoxidil or minoxidil and dutasteride.