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    GlossaryCalcineurin Inhibitors

    medications that suppress immune response by blocking calcineurin activity

    Calcineurin inhibitors (CNIs) are a class of medications that suppress the immune system by blocking the activity of calcineurin, a protein involved in activating T-cells. They are commonly used to prevent organ transplant rejection and to treat autoimmune diseases. In dermatology, CNIs like tacrolimus and pimecrolimus are used topically to manage conditions such as atopic dermatitis and certain types of alopecia, as they help reduce inflammation and immune response in the skin.

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      community Topical - Lantoprost .01%, MIN 10% DUT .05%, Hydrocortisone 1% Progrestron .025%

      in Treatment  5 upvotes 1 week ago
      A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.