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GlossaryCalcineurin Inhibitors

medications that suppress immune response by blocking calcineurin activity

Calcineurin inhibitors (CNIs) are a class of medications that suppress the immune system by blocking the activity of calcineurin, a protein involved in activating T-cells. They are commonly used to prevent organ transplant rejection and to treat autoimmune diseases. In dermatology, CNIs like tacrolimus and pimecrolimus are used topically to manage conditions such as atopic dermatitis and certain types of alopecia, as they help reduce inflammation and immune response in the skin.

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research Management of Alopecia Areata

May 2018

Alopecia Areata is treated with drugs and therapies to reduce inflammation and immune response.

research Central Centrifugal Cicatricial Alopecia: Challenges and Solutions

37 citations , August 2016 in “Clinical, Cosmetic and Investigational Dermatology”

The document concludes that better treatments for CCCA are needed and more research is required to understand its causes related to hairstyling and genetics.

research Update on Frontal Fibrosing Alopecia

2 citations , April 2017 in “Actas Dermo-Sifiliográficas”

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

research Frontal Fibrosing Alopecia: An Update on Epidemiology and Treatment

7 citations , October 2015 in “Actas Dermo-Sifiliográficas”

New treatments for Frontal Fibrosing Alopecia show promise, especially finasteride and dutasteride, with most patients seeing improvement or stabilization.

research Overview of Lichen Planopilaris: Diagnosis and Treatment

July 2018 in “Elsevier eBooks”

Lichen Planopilaris is a hair loss condition best treated early with various medications, including hydroxychloroquine, to prevent permanent baldness.

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community Topical - Lantoprost .01%, MIN 10% DUT .05%, Hydrocortisone 1% Progrestron .025%

in Treatment 6 upvotes 6 months ago

A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I had claude create a protocol only using fda approved drugs.

in Research/Science 2 upvotes 2 months ago

A new hair loss protocol using FDA-approved topical treatments targets eight pathways, potentially improving results by 60-75% compared to the standard 40-50% from oral minoxidil and finasteride. The protocol includes minoxidil, finasteride, tacrolimus, cetirizine, bimatoprost, lithium gluconate, losartan, melatonin, NAC, caffeine, and tretinoin, with a monthly cost of $35-50 in Mexico and $80-150 in the US.

community Making your own RT1640 in China

in Research/Science 4 years ago

RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.