Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma
August 2019
in “
International journal of dermatology and venereology
”
Studysummary This review discusses the calcineurin/NFAT pathway's role in cutaneous squamous cell carcinoma, noting its involvement in tumor development, skin cell behavior, and the tumor microenvironment; it reports no new results. Our plain-language summary of this paper — not a Tressless recommendation.
The study reviewed the role of the calcineurin/NFAT pathway in cutaneous squamous cell carcinoma (CSCC), noting that calcineurin inhibitors, used as immunosuppressants, were linked to a higher incidence of CSCC compared to mTOR inhibitors. The pathway was crucial in tumor initiation and development, with NFATc1 maintaining skin stem cell quiescence but promoting tumor formation when activated. Dysregulation of this pathway contributed to abnormal keratinocyte behavior and tumorigenesis. The study emphasized the need for further research on isoform-specific NFAT functions in CSCC and suggested potential therapeutic benefits of targeting the NFAT pathway to manage CSCC.
