research Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation
Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.
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research Investigation of the Role of SIRT3, SIRT7, NFATC1, and PDL-1 Genes in Androgenetic Alopecia
SIRT3 and SIRT7 decrease, while NFATC1 and PDL-1 increase in Androgenetic Alopecia.
research MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata
A substance called miR-1246 may help treat severe hair loss by reducing certain immune cell activities.
research Investigation of the Role of SIRT3, SIRT7, NFATC1, and PDL-1 Genes in Androgenetic Alopecia
This study investigates the role of SIRT3, SIRT7, NFATC1, and PDL-1 genes in androgenetic alopecia (AGA), focusing on their expression patterns during hair follicle aging. Researchers analyzed mesenchymal stem cells from six men with AGA, finding that SIRT3 and SIRT7 expression levels, which typically decrease with hair follicle aging, were also reduced in AGA samples. Conversely, NFATC1 and PDL-1, which usually increase with aging, were elevated in AGA samples. Bioinformatic analyses support the involvement of SIRT3, SIRT7, and NFATC1 in AGA pathogenesis. While SIRT3 and SIRT7 are suggested to play critical roles in AGA development, further research is needed to understand the significance of NFATC1 and PDL-1 and their potential as therapeutic targets.
research Epidermal Stem Cell Diversity and Quiescence
Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.
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