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regulates immune response, inflammation, and cell survival

NF-κB signaling, short for Nuclear Factor kappa-light-chain-enhancer of activated B cells signaling, is a critical pathway in the body that helps regulate the immune response, inflammation, and cell survival. When activated, NF-κB proteins move into the cell nucleus and turn on specific genes that help the body respond to stress, infections, and other threats. This pathway is important in many diseases, including cancer and autoimmune disorders, because it can influence how cells grow and survive.

Related Terms

• Inflammatory signaling pathways
• Transcription factors
• Cell signaling
• NF-κB
• NF-κB activation
• IκB kinase
• NF-κB pathway
• Receptor Activator of Nuclear Factor Kappa-Β Ligand
• NFATc3
• Nuclear factor erythroid 2-related factor 2