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GlossaryNFATc4

protein regulating gene expression in immune and hair follicle cells

NFATc4 stands for Nuclear Factor of Activated T-cells, cytoplasmic 4. It is a protein that plays a crucial role in the regulation of gene expression in response to various signals, particularly in the immune system. In the context of hair biology, NFATc4 can influence the growth and development of hair follicles by regulating the expression of specific genes involved in these processes.

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Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

Polysaccharides from Traditional Chinese Medicines: Extraction, Purification, Modification, and Biological Activity

research Polysaccharides from Traditional Chinese Medicines: Extraction, Purification, Modification, and Biological Activity

125 citations, December 2016 in “Molecules”

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

29 citations, March 2015 in “Journal of Investigative Dermatology”

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions

research Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions

24 citations, October 2017 in “Scientific reports”

Changing light exposure can affect hair growth timing in goats, possibly due to a key gene, CSDC2.

Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice

research Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice

22 citations, May 2021 in “Nature Communications”

Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

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