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GlossaryNFATc3

regulates gene expression in immune responses

NFATc3, or Nuclear Factor of Activated T-Cells, Cytoplasmic 3, is a protein that plays a crucial role in the immune system by regulating the expression of genes involved in immune responses. It is part of the NFAT family of transcription factors, which are activated in T-cells and other immune cells to help control inflammation and the body's defense mechanisms.

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research Targeting the Wnt Pathways for Therapies

112 citations, January 2014 in “Molecular and cellular therapies”

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations, June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

54 citations, November 2017 in “Scientific Reports”

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

research Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels

40 citations, March 2019 in “Nature Communications”

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

29 citations, March 2015 in “Journal of Investigative Dermatology”

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

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