Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

    June 2003 in “ American Journal of Physiology-cell Physiology ”
    Anat Gafter-Gvili, Benjamin Sredni, Rivka Gal, Uzi Gafter, Yona Kalechman
    Image of study
    TLDR Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.
    The document from June 1, 2003, presents a study on the effects of Cyclosporin A (CsA) on hair growth in mice, revealing that CsA promotes hair growth by inhibiting the calcineurin-dependent activation of NFAT in follicular keratinocytes. The study showed that CsA treatment led to dose-dependent hair growth in nude mice and delayed the catagen phase in C57BL/6 mice. It also altered the expression of various genes and proteins associated with hair follicle regression and differentiation, such as increasing the Bcl-2/Bax ratio and decreasing p53 expression. These findings suggest that CsA could be a potential treatment for hair growth disorders by delaying keratinocyte terminal differentiation and catagen induction. The study involved groups of three mice, indicating a relatively small sample size.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 15 results

      community RT1640 - Gray Hair Reversal Recipe

      in Research/Science  3 upvotes 2 years ago
      The conversation discusses a hair loss treatment formulation containing cyclosporin, minoxidil, and tacrolimus, and mentions ongoing research on hair color reversal. The treatment showed high efficacy in restoring hair color in trials with 40 to 50 people.

      community Starting Way-316606 for the first time today.

      in Research/Science  30 upvotes 2 weeks ago
      A user is experimenting with a homemade solution of WAY-316606 for hair regrowth, combining it with other treatments like minoxidil and dutasteride. The community expresses concern over the safety and mental health implications of such drastic measures, with mixed opinions on the effectiveness of WAY-316606.

      community The most nuclear stack possible

      in Satire  37 upvotes 1 week ago
      A user humorously suggests an extreme hair loss treatment regimen involving multiple medications and therapies, including Dutasteride, Minoxidil, RU58841, and others, claiming it would prevent hair loss but with potential side effects like gynecomastia. The conversation highlights concerns about safety, side effects, and the effectiveness of such a comprehensive approach.

    Related Research

    5 / 5 results