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GlossaryNFATc1

protein regulating gene expression in immune and hair follicle cells

NFATc1, or Nuclear Factor of Activated T-Cells, cytoplasmic 1, is a protein that plays a crucial role in the regulation of gene expression in immune cells, particularly T-cells. It is involved in the activation of immune responses and has also been implicated in various biological processes, including the development and function of hair follicles.

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Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations, June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

research Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation

40 citations, April 2014 in “Genes & Development”

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata

research MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata

January 2023 in “Annals of dermatology/Annals of Dermatology”

A substance called miR-1246 may help treat severe hair loss by reducing certain immune cell activities.

research Cyclosporin A Suppresses TGF-Beta2 Expression Via Calcineurin/NFAT Pathway in Human Dermal Papilla Cells

April 2023 in “Journal of Investigative Dermatology”

Cyclosporin A, a drug, reduces TGF-β2 expression in skin cells, potentially causing excessive hair growth through a process involving the calcineurin/NFAT pathway.

research Investigation of the Role of SIRT3, SIRT7, NFATC1, and PDL-1 Genes in Androgenetic Alopecia

July 2024 in “Research Square (Research Square)”

SIRT3 and SIRT7 decrease, while NFATC1 and PDL-1 increase in Androgenetic Alopecia.

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