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GlossaryNFATc1

protein regulating gene expression in immune and hair follicle cells

NFATc1, or Nuclear Factor of Activated T-Cells, cytoplasmic 1, is a protein that plays a crucial role in the regulation of gene expression in immune cells, particularly T-cells. It is involved in the activation of immune responses and has also been implicated in various biological processes, including the development and function of hair follicles.

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research Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells

415 citations , January 2008 in “Cell”

NFATc1 controls hair stem cell activity, affecting hair growth and could be a target for hair loss treatments.

Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes

57 citations , June 2003 in “American Journal of Physiology-cell Physiology”

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

research NFAT5 Mediates Hypertonic Stress-Induced Atherosclerosis via Activating NLRP3 Inflammasome in Endothelium

50 citations , August 2019 in “Cell Communication and Signaling”

NFAT5 triggers atherosclerosis under stress by activating inflammation in blood vessels.

research Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation

40 citations , April 2014 in “Genes & Development”

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata

research MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata

January 2023 in “Annals of dermatology/Annals of Dermatology”

A substance called miR-1246 may help treat severe hair loss by reducing certain immune cell activities.

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