Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels

March 2019 in “ Nature Communications ”

Martin Vaeth, Yin Hu Wang, Miriam Eckstein, Jun J. Yang, Gregg J. Silverman, Rodrigo S. Lacruz, Kasthuri Kannan, Stefan Feske

calcium release-activated calcium channels CRAC channels regulatory T cells Treg cells STIM1 STIM2 follicular Treg cells Tfr cells tissue-resident Treg cells autoimmune hemolytic anemia AIHA store-operated calcium entry SOCE calcium signaling immune tolerance autoimmunity

Studysummary This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.

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