Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels

    March 2019 in “ Nature Communications ”
    Martin Vaeth, Yin Hu Wang, Miriam Eckstein … Stefan Feske
    Studysummary This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.
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