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Glossary Calcium Signaling

process where calcium ions regulate cellular functions

Calcium signaling, also known as Ca2+ signaling, is a process where calcium ions (Ca2+) act as a signal within cells to regulate various functions such as muscle contraction, neurotransmitter release, and gene expression. When calcium ions enter the cell or are released from internal stores, they bind to proteins and trigger specific cellular responses, making it a crucial mechanism for maintaining cellular activities and overall physiological balance.

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Research

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research Cell cycle controls long-range calcium signaling in the regenerating epidermis

22 citations , April 2023 in “The Journal of Cell Biology”

In this study, researchers found that coordinated intercellular Ca2+ signaling among basal stem cells in mice is crucial for cell cycle progression and tissue-wide communication during epidermal regeneration.

research Role of vitamin D and calcium signaling in epidermal wound healing

15 citations , August 2022 in “Journal of endocrinological investigation”

This review discusses how vitamin D and calcium signaling are essential for wound healing by activating epidermal and hair follicle stem cells, noting that deficiencies may lead to delayed or chronic wounds.

research Vitamin D and calcium signaling in epidermal stem cells and their regeneration

13 citations , July 2020 in “World journal of stem cells”

This review discusses vitamin D and calcium signaling roles in epidermal stem cell processes essential for wound healing but reports no new experimental results, emphasizing their potential interdependent regulatory mechanisms.

research G2 stem cells orchestrate time-directed, long-range coordination of calcium signaling during skin epidermal regeneration

4 citations , October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that epidermal stem cells in live mice exhibit coordinated intercellular Ca 2+ signaling governed by G2 cycling stem cells and mediated by Connexin43, essential for tissue-wide communication during regeneration.

research PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence

May 2025 in “Science Advances”

In this study, researchers reported that hair follicle stem cells maintain quiescence through a PIEZO1-dependent mechanism that senses mechanical forces and translates them into localized calcium influx, involving a transcriptional network that regulates cell adhesion and cytoskeleton-related genes.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 1 month ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

community 4 months, only Minoxidil 5% ,dermarolling twice a week. hair growth results. any suggestions?

462 upvotes 1 year ago

Significant hair growth was achieved using Minoxidil 5% and dermarolling twice a week, with suggestions to add finasteride for maintenance. There is debate on when to apply Minoxidil after dermarolling to avoid irritation.

community DIM + Calcium d-Glucarate (lowering Estrogen)

4 upvotes 3 years ago

Using DIM and Calcium D-Glucarate to reduce finasteride side effects. Discussion includes dosage, brand, and product effectiveness.

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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