Role of Vitamin D and Calcium Signaling in Epidermal Wound Healing

    Daniel Bikle
    Studysummary This review discusses how vitamin D and calcium signaling are essential for wound healing by activating epidermal and hair follicle stem cells, noting that deficiencies may lead to delayed or chronic wounds.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 18

    1. Vitamin D and Calcium Signaling in Epidermal Stem Cells and Their Regeneration World journal of stem cells · 2020
    2. Calcium Regulation of Stem Cells EMBO reports · 2020
    3. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    4. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    5. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization Endocrinology · 2017
    6. Vitamin D And Calcium Regulation Of Epidermal Wound Healing The Journal of Steroid Biochemistry and Molecular Biology · 2015
    7. Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing British Journal of Dermatology · 2015
    8. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014
    9. Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche Nature Reviews Molecular Cell Biology · 2013
    10. Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-Beta Signaling During the Inflammatory Response to Cutaneous Injury Endocrinology · 2012
    11. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    12. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    13. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    14. The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    15. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    16. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    17. Vitamin D Receptor Is Essential For Normal Keratinocyte Stem Cell Function Proceedings of the National Academy of Sciences · 2007
    18. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005

    Related research 1

    1. The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation Journal of Dermatological Science · 2017