Role of Vitamin D and Calcium Signaling in Epidermal Wound Healing

August 2022 in “ Journal of endocrinological investigation ”

Daniel Bikle

vitamin D calcium signaling epidermal wound healing stem cells hair follicles vitamin D receptors calcium receptors VDR CaSR Med 1 complex beta-catenin p63 E-cadherin/catenin complex re-epithelialization chronic wounds calcium wound healing Med 1 E-cadherin

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Vitamin D →

vitamin you should probably be taking for general health might also help your hair a little

calcium →

Studysummary This review discusses how vitamin D and calcium signaling are essential for wound healing by activating epidermal and hair follicle stem cells, noting that deficiencies may lead to delayed or chronic wounds.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This review highlights the importance of vitamin D and calcium signaling in the process of epidermal wound healing, focusing on the role they play in the activation and function of stem cells in the epidermis and hair follicles. It is shown that vitamin D and calcium receptors (VDR and CaSR) are crucial for stem cells to effectively respond to wounds, as their deletion leads to slower wound healing. The review also notes that vitamin D regulates the VDR through co-regulators like the Med 1 complex and interacts with other transcription factors such as beta-catenin and p63. The formation of the E-cadherin/catenin complex, stimulated by vitamin D and calcium, is essential for the stem cells' activation, migration, and re-epithelialization during wound repair. The review concludes that deficiencies in vitamin D and calcium can lead to delayed healing or chronic wounds, which are significant health concerns due to their impact on morbidity, productivity, and healthcare costs.

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Research cited in this study

18 / 18 results

research Vitamin D and Calcium Signaling in Epidermal Stem Cells and Their Regeneration

13 citations , July 2020 in “World journal of stem cells”

This review discusses vitamin D and calcium signaling roles in epidermal stem cell processes essential for wound healing but reports no new experimental results, emphasizing their potential interdependent regulatory mechanisms.

research Calcium Regulation of Stem Cells

25 citations , May 2020 in “EMBO reports”

This review discusses the potential roles of calcium in the regulation of pluripotent and tissue-specific stem cells but reports no new experimental results, highlighting areas for future research.

research Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing

209 citations , October 2018 in “Cell Reports”

This study found that Lgr5 and Lgr6 stem cells both activated wound-healing genes, but only Lgr5 stem cells changed their identity to contribute to new skin formation during wound repair.

Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair

research Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair

46 citations , May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the vitamin D receptor is essential for the self-renewal, migration, and differentiation of epidermal stem cells during skin wound healing in mice.

research Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization

28 citations , March 2017 in “Endocrinology”

In this study, the researchers found that vitamin D and calcium signaling in keratinocytes are essential for normal skin regeneration after wounding, with deficiencies significantly delaying wound closure and re-epithelialization in mice.

research Vitamin D And Calcium Regulation Of Epidermal Wound Healing

86 citations , August 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study suggests that vitamin D and calcium signaling play a crucial role in wound healing by regulating stem cell activation through enhanced β-catenin transcriptional activity in mice.

research Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing

908 citations , July 2015 in “British Journal of Dermatology”

This article reviews the cellular and molecular processes of acute and chronic wound healing, emphasizing the need for collaboration between researchers and clinicians to advance therapeutic solutions; it presents no new clinical results.

research Lineage Analysis of Epidermal Stem Cells

57 citations , January 2014 in “Cold Spring Harbor Perspectives in Medicine”

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

research Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche

133 citations , September 2013 in “Nature Reviews Molecular Cell Biology”

Different types of stem cells and their environments are key to skin repair and maintenance.

research Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-Beta Signaling During the Inflammatory Response to Cutaneous Injury

56 citations , November 2012 in “Endocrinology”

This study found that the absence of vitamin D receptor signaling in mice impairs the inflammatory response to skin injury, particularly affecting macrophage recruitment and granulation tissue formation.

research Epithelial Stem Cells And Implications For Wound Repair

156 citations , October 2012 in “Seminars in Cell & Developmental Biology”

This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.

research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations

41 citations , December 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reported that deleting the MED1 subunit from the MED complex in keratinocytes resulted in disrupted hair differentiation and cycling, leading to hair loss in mice.

research Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

503 citations , May 2009 in “Cell stem cell”

This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.

research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment

25 citations , March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that while VDR is crucial for maintaining hair follicles in mice, their degeneration may be linked to impaired cell migration during hair growth phases rather than stem cell loss.

research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

127 citations , January 2008 in “PloS one”

This study observed that the vitamin D receptor is crucial for hair follicle formation and altering tumor development in the Wnt signaling pathway, suggesting therapeutic potential for vitamin D analogues in related tumors.