Vitamin D And Calcium Regulation Of Epidermal Wound Healing

August 2015 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

Yuko Oda, Chia-Ling Tu, Alicia Menéndez, Thai Nguyen, Daniel D Bikle, Yuko Oda, Chia-Ling Tu, Alicia Menéndez, Thai Nguyen, Daniel D Bikle

vitamin D calcium epidermal wound healing β-catenin signaling vitamin D receptor VDR keratinocytes epidermal stem cells hair follicle cycling alopecia wound healing hair loss

TLDR Vitamin D and calcium are essential for effective wound healing and hair growth.

The study explored the role of vitamin D and calcium in epidermal wound healing, focusing on β-catenin signaling. It was found that mice lacking the vitamin D receptor (VDR) and on a low calcium diet exhibited delayed wound healing. This delay was linked to reduced β-catenin transcriptional activity and decreased proliferation and migration of keratinocytes at the wound edge. The findings suggested that vitamin D and calcium are crucial for activating epidermal stem cells through β-catenin signaling, which is essential for effective wound healing. Additionally, the study highlighted the importance of VDR in hair follicle cycling, with its absence leading to alopecia due to impaired stem cell activation.

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Research cited in this study

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