Cutaneous Wound Healing: Recruiting Developmental Pathways for Regeneration

    October 2012 in “ Cellular and Molecular Life Sciences ”
    Kirsten A. Bielefeld, Saeid Amini‐Nik, Benjamin A. Alman
    Studysummary This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on link.springer.com →
    Discuss this study in the Community →

    Research cited in this study 22

    1. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    2. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    3. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    4. Ultrafast Mid-IR Laser Scalpel: Protein Signals of the Fundamental Limits to Minimally Invasive Surgery PLoS ONE · 2010
    5. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    6. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    7. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    8. Hedgehog Signaling Is Essential For Normal Wound Healing Wound Repair and Regeneration · 2008
    9. Memory Encoded Throughout Our Bodies: Molecular and Cellular Basis of Tissue Regeneration Pediatric Research · 2008
    10. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    11. Wnt Signaling in Skin Organogenesis Organogenesis · 2008
    12. The Role of Smads in Skin Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    13. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    14. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    15. Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development Developmental Cell · 2006
    16. Hedgehog Signaling in Skin Development and Cancer Experimental Dermatology · 2006
    17. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    18. Ontogenetic Transition in Fetal Wound Transforming Growth Factor-Beta Regulation Correlates with Collagen Organization American Journal of Pathology · 2003
    19. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    20. Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators Developmental dynamics · 2000
    21. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    22. Expression of Transforming Growth Factor-Beta (TGF-Beta 1) and Insulin-Like Growth Factor II (IGF-II) Messenger RNA in the Developing Subcutaneous Tissue of the Fetal Pig PubMed · 1992