Cutaneous Wound Healing: Recruiting Developmental Pathways for Regeneration

    October 2012 in “ Cellular and Molecular Life Sciences ”
    Kirsten A. Bielefeld, Saeid Amini‐Nik, Benjamin A. Alman
    TLDR Understanding developmental pathways can improve wound healing treatments.
    The document discussed the differences between postnatal cutaneous wound repair and embryonic skin development in mammals, highlighting that repaired skin is not identical to uninjured skin. It emphasized the importance of understanding molecular pathways, such as Wnt/β-catenin, TGF-β, Hedgehog, and Notch, which play roles in both wound repair and skin development. The study compared responses to cutaneous injury across different species, noting variations from complete regeneration to scar formation. It concluded that research into these developmental pathways has informed current wound therapies and holds promise for developing more effective treatments.
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