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Glossary Notch2

gene involved in cell differentiation and developmental processes

Notch2 is a gene that plays a crucial role in cell differentiation, which is the process by which cells become specialized for specific functions. It is part of the Notch signaling pathway, a fundamental communication system that cells use to control various developmental processes and maintain tissue homeostasis. Mutations in Notch2 can lead to various medical conditions, including certain types of cancer and developmental disorders.

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Research

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research Epidermal Notch signalling: differentiation, cancer and adhesion

253 citations , April 2008 in “Current opinion in cell biology”

This study found that Notch signalling promotes differentiation of epidermal cells and acts as a tumour suppressor in the skin by interacting with various pathways and mechanisms.

research Mouse notch: expression in hair follicles correlates with cell fate determination.

150 citations , May 1993 in “The journal of cell biology/The Journal of cell biology”

This study suggests that mNotch expression plays a significant role in hair follicle differentiation and cell fate selection within the follicle during development.

research The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

134 citations , January 2011 in “Development”

This study found that disrupting Adam10 in the epidermis led to severe skin and multi-organ abnormalities, implicating Adam10 as crucial for proper Notch signaling and skin maintenance.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.

research Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology

112 citations , January 2013 in “Experimental dermatology”

This article offers a viewpoint on hidradenitis suppurativa pathogenesis, suggesting that impaired Notch signalling from γ-secretase mutations may drive inflammation and link the condition to other Th17-driven diseases.

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community Nothing happened till I was exactly 11 months off fin+min

4 upvotes 2 weeks ago

After stopping finasteride and minoxidil, the user experienced significant hair shedding 11 months later, despite not noticing any hair loss during that period. The user initially took these treatments to regrow temple hair but did not see significant results and is now concerned about the delayed shedding.

community Nothing compensates enough for hair loss at young age.

in Chat 66 upvotes 11 months ago

Early hair loss causes emotional distress, and common coping strategies like fitness and fashion are inadequate. Treatments like finasteride, minoxidil, dutasteride, hair systems, and scalp micropigmentation were tried but were unsatisfactory.

community Nothing seems to stop my receding hairline and thinning

1 upvotes 1 year ago

The user has tried various treatments for hair loss, including finasteride, dutasteride, RU58841, Pyrilutamide, and several topical growth factors, but continues to experience a receding hairline and thinning. Despite maintaining a healthy lifestyle, the user is unsure why these treatments are ineffective and seeks advice on the underlying cause.

community Nothing Has Stopped My Pre-treatment Shedding

4 upvotes 1 year ago

The user is frustrated with ongoing hair loss despite using oral finasteride and topical minoxidil. They are considering adding magnesium to their diet and exploring other treatments like micro-needling and keto shampoo.

community There’s nothing better on the horizon [RANT]

22 upvotes 1 month ago

There is skepticism about new hair loss treatments, with the belief that current options like minoxidil, finasteride, and hair transplants are the best available. Concerns are raised about the systemic side effects of androgen-related treatments, even those marketed as topical, and doubts about the effectiveness of emerging treatments like clascoterone.

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