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    Glossary Notch4

    gene involved in cell signaling affecting hair follicle development

    Notch4 is a gene that encodes a protein involved in cell signaling, which plays a crucial role in the development and function of various tissues, including the vascular system and the immune system. In the context of hair and alopecia, Notch4 signaling can influence hair follicle development and cycling, potentially impacting hair growth and loss.

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    1. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    2. Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology Experimental dermatology · 2013 · 112 citations
    3. Localisation of members of the notch system and the differentiation of vibrissa hair follicles: Receptors, ligands, and fringe modulators Developmental dynamics · 2000 · 62 citations
    4. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011 · 61 citations
    5. JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing Scientific Reports · 2017 · 54 citations
    6. Pleiotropic Role of Notch Signaling in Human Skin Diseases International Journal of Molecular Sciences · 2020 · 29 citations
    7. Role of Aire and Notch4 Allelic Mutations in Alopecia Areata in C3H/HeJ Mice JID Innovations · 2026
    8. Epidermal Notch1 recruits innate lymphoid cells to orchestrate normal skin repair Durham e-Theses (Durham University) · 2014
    9. Mouse notch: expression in hair follicles correlates with cell fate determination. 1993 · 150 citations
    10. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
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