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GlossaryNotch signaling

cell communication system regulating development and tissue maintenance

Notch signaling is a fundamental communication system used by cells to control various developmental processes and maintain tissue homeostasis. It involves interactions between neighboring cells through the Notch receptor and its ligands, leading to changes in gene expression that influence cell fate decisions, such as differentiation, proliferation, and apoptosis. This pathway is crucial in many biological contexts, including the development of hair follicles and the regulation of stem cells.

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research Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway

36 citations, April 2016 in “Biochimie”

A substance called epidermal growth factor helps increase the growth of important hair follicle cells by activating a specific cell communication route.

Pantothenic Acid Promotes Dermal Papilla Cell Proliferation in Hair Follicles of American Minks via Inhibitor of DNA Binding 3/Notch Signaling Pathway

research Pantothenic Acid Promotes Dermal Papilla Cell Proliferation in Hair Follicles of American Minks via Inhibitor of DNA Binding 3/Notch Signaling Pathway

11 citations, April 2020 in “Life sciences”

Pantothenic acid helps mink hair follicles grow by affecting certain cell signals.

research Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately

113 citations, June 2015 in “Stem Cell Research & Therapy”

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

Adipose Mesenchymal Stem Cells Combined with Platelet-Rich Plasma Accelerate Diabetic Wound Healing by Modulating the Notch Pathway

research Adipose Mesenchymal Stem Cells Combined with Platelet-Rich Plasma Accelerate Diabetic Wound Healing by Modulating the Notch Pathway

39 citations, July 2021 in “Stem Cell Research & Therapy”

Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.

research Notch Signaling in Hair Follicle Development

September 2017 in “Asian Journal of Beauty and Cosmetology”

The Notch signaling pathway is important for hair follicle development and could help create treatments for hair disorders.

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community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 1 year ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community Had my 6 month checkup today and saw better results than I thought. More full up top and my facial hair has also gotten fuller as well

in Progress Pictures 285 upvotes 2 years ago

A user who has seen results of hair regrowth after 6 months of using finasteride 1.25mg daily, and topical foam minoxidil twice a day for 3 months before switching to once a day; other users have advised against increasing the dose of finasteride due to lack of additional scalp DHT reduction and increased risk of side effects.

community [19M] Before and after pics 8 months after consistent use of Finasteride 1 mg and Minoxidil 5% 1ml every night, ketokonazole2%+salicylic acid mild shampoo everyday. I've used minoxidil only for the frontal, most significant area of the scalp for regrowth as 1 ml is not enough for entire scalp

in Progress Pictures 224 upvotes 2 years ago

User shared before and after photos of 8 months using Finasteride 1mg and Minoxidil 5% 1ml nightly, with positive results and no side effects. Others praised the progress and suggested alternative treatments like topical fin, CB-03-01, or RU58841.

community Front page article at The New York Times (biggest circulation in the world) regarding notable results with oral minoxidil is a pretty big deal

in Minoxidil 2 years ago

This conversation discusses the potential benefits of using oral minoxidil and finasteride to treat hair loss, with some users sharing their own experiences in taking the medications. Others express concerns about the safety of these treatments.

community Before and After - My journey so far

in Progress Pictures 573 upvotes 7 months ago

A 28-year-old used oral finasteride and minoxidil, and underwent two hair transplants in Turkey, with a total of 3150 grafts, resulting in a natural-looking hairline. The first procedure cost £3300, and the second was a free touch-up, with additional costs for flights and accommodation.

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