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Glossary Notch receptors

proteins on cell surfaces crucial for cell communication and development

Notch receptors are proteins found on the surface of cells that play a crucial role in cell communication and development. They help regulate cell fate decisions, meaning they influence how cells grow, divide, and specialize, which is essential for processes like hair growth and skin regeneration.

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Research

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Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators

research Localisation of members of the notch system and the differentiation of vibrissa hair follicles: Receptors, ligands, and fringe modulators

62 citations , January 2000 in “Developmental dynamics”

This study found that Notch-related genes, including Notch1 and Notch2, and their ligands and regulators, have distinct patterns of expression during mouse hair vibrissa follicle development and the adult hair cycle.

Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations

research Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg–like Cells, and Common EGFR Somatic Mutations

4 citations , May 2021 in “The American Journal of Surgical Pathology”

This study suggests that cutaneous lymphadenoma is a distinct benign lymphoepithelial tumor characterized by androgen receptor expression, hair follicle stem cell markers, and common EGFR gene mutations.

research Molecular mechanisms of ectodermal dysplasia syndromes

3 citations , June 2004 in “Työväentutkimus Vuosikirja”

This article reviews the roles of several signaling pathways and molecules, including FGFs, Hh, Notch, TGF, and Wnt, in the development of teeth and hair follicles, but reports no new findings.

research Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

181 citations , January 2019 in “Cell”

In this research, authors found that skin-resident ILCs regulate sebaceous gland function and microbial balance, emphasizing an immune-epithelia system that supports host-microbe symbiosis.

research Molecular biology of hair morphogenesis: Development and cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.

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Community Join

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community Joined the Dutasteride Master Race

586 upvotes 1 year ago

Dutasteride and finasteride are discussed for hair loss treatment, with users sharing experiences and debating their effectiveness and side effects. Celebrities are noted as common users, and there is debate over which treatment is superior.

community Yes your lifestyle and diet has its role in hair loss.

in Chat 296 upvotes 1 year ago

Diet and lifestyle changes can reduce hair shedding but won't regrow hair lost to genetic male pattern baldness. Treatments like finasteride and dutasteride are necessary for significant hair regrowth.

community 3 years on meds and my hair looks like this. Not sure if they are working.

in Minoxidil 4 upvotes 1 month ago

The user has been using minoxidil and finasteride for hair loss but hasn't seen positive results, experiencing side effects like dry eyes and possible seborrheic dermatitis. Suggestions include adding dutasteride, using ketoconazole shampoo, microneedling, and waiting longer for results.

community Is this real chat? Finasteride -> fountain of youth and longevity drug?

559 upvotes 1 year ago

Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

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