Transient Efficacy of Tofacitinib in Alopecia Areata Universalis

The document described a single case study of a 51-year-old man with alopecia areata universalis who experienced temporary hair regrowth after three months of treatment with tofacitinib, a Janus kinase inhibitor. However, the drug's efficacy diminished within a month, leading to hair loss again. This case underscores the uncertainty of long-term efficacy of Janus kinase inhibitors for treating alopecia areata and indicates the necessity for more extensive research, such as randomized clinical trials, to evaluate the potential of these medications for this condition.