Transient Efficacy of Tofacitinib in Alopecia Areata Universalis

    April 2016 in “ Case Reports in Dermatology ”
    Florian Anzengruber, Julia‐Tatjana Maul, Jivko Kamarachev … Alexander A. Navarini
    Studysummary This study observed initial hair regrowth in a businessman with alopecia areata universalis treated with tofacitinib, but the effect diminished, leading to renewed hair loss.
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    Research cited in this study 12

    1. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    2. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    3. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    4. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014
    5. Overview of Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2013
    6. Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment Gut · 2013
    7. Genetic Basis of Alopecia Areata Dermatologic clinics · 2012
    8. Alopecia Areata: An Autoimmune Disease Causing Hair Loss Recent Patents on Inflammation & Allergy Drug Discovery · 2011
    9. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    10. Interventions for Alopecia Areata Cochrane library · 2008
    11. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    12. The Pathogenesis of Alopecia Areata Dermatologic Clinics · 1996

    Related research 1

    1. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients International Journal of Trichology · 2018