Beta-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding

    February 2018 in “ Plastic and Reconstructive Surgery ”
    Antoine L. Carre, Michael S. Hu, Aaron W. James, Kenichiro Kawai, Michael G. Galvez, Michael T. Longaker, H. Peter Lorenz
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    TLDR The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.
    The document describes a study investigating the impact of β-catenin-dependent Wnt signaling on acute cutaneous wound healing and scar formation. The researchers observed an increase in the expression of Wnt ligands such as Wnt3a, Wnt4, Wnt10a, and Wnt11 in the hair follicle and epidermis after creating wounds on mice. Treatment with recombinant mouse Wnt3a (rmWnt3a) led to faster wound closure, larger scars, and higher expression of fibroblast growth factor receptor-2 and type I collagen. The study demonstrated that Wnt signaling is upregulated following skin injury and that rmWnt3a can enhance reepithelialization, wound matrix maturation, and scar formation. The study used 7 mice for the wound closure analysis and 3 mice for gene expression analyses. Future research will explore the regulation of other Wnt ligands that increase after wounding.
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