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Beta-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding

February 2018 in “ Plastic and Reconstructive Surgery ”

Antoine L. Carre, Michael S. Hu, Aaron W. James, Kenichiro Kawai, Michael G. Galvez, Michael T. Longaker, H. Peter Lorenz

β-catenin Wnt signaling acute cutaneous wound healing scar formation Wnt ligands Wnt3a Wnt4 Wnt10a Wnt11 hair follicle epidermis recombinant mouse Wnt3a rmWnt3a fibroblast growth factor receptor-2 type I collagen reepithelialization wound matrix maturation FGFR2 collagen

Studysummary The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.

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Research cited in this study

8 / 8 results

Fibroblasts Become Fat to Reduce Scarring

research Fibroblasts Become Fat to Reduce Scarring

13 citations , February 2017 in “Science”

Turning scar-forming cells into fat cells can reduce scarring.

Regeneration of Fat Cells from Myofibroblasts During Wound Healing

research Regeneration of Fat Cells from Myofibroblasts During Wound Healing

408 citations , January 2017 in “Science”

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

Scarless Wound Healing: Finding the Right Cells and Signals

research Scarless Wound Healing: Finding the Right Cells and Signals

132 citations , June 2016 in “Cell and Tissue Research”

This review discusses recent advancements in scar reduction techniques, highlighting promising therapeutic targets and the role of Wnt/β-catenin signaling in promoting scarless wound healing, but reports no new clinical results.

Inhibition of Wnt/β-Catenin Pathway Promotes Regenerative Repair of Cutaneous and Cartilage Injury

research Inhibition of Wnt/β-Catenin Pathway Promotes Regenerative Repair of Cutaneous and Cartilage Injury

41 citations , August 2015 in “The FASEB Journal”

The researchers reported that topical application of small-molecule Wnt inhibitors significantly reduced fibrosis and promoted regenerative wound healing in mice.

Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing

research Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing

61 citations , October 2013 in “PLoS ONE”

This study found that amplifying Wnt signaling, either genetically or through topical application of liposomal Wnt3a, improved skin wound healing in a mouse model.

Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations , June 2013 in “Nature Medicine”

This study found that fibroblast growth factor 9, initially secreted by γδ T cells, plays a key role in modulating hair follicle regeneration in mice after skin wounds.

Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing

159 citations , January 2006 in “BMC Cell Biology”

This study found that manipulating Wnt signaling pathways in cutaneous wounds can induce skin structures resembling regeneration, suggesting a potential role for Wnt signals in restoring skin architecture during wound healing.