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research Beta-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding
The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.
research SFRP2 Augments Wnt/β-Catenin Signalling in Cultured Dermal Papilla Cells
SFRP2 boosts Wnt3a/β-catenin signals in hair growth cells, with stronger effects in beard cells than scalp cells.
research Establishment and Characterization of Five Immortalized Human Scalp Dermal Papilla Cell Lines
Researchers created five new human scalp cell lines that could be useful for hair growth and loss research.
research Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells
Androgens slow hair growth by altering Wnt signaling in balding cells.
research The G1/S Transition in Mammalian Stem Cells In Vivo Is Autonomously Regulated by Cell Size
Cell size controls when stem cells divide.
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5 / 10 resultscommunity SCUBE3 is going to save us!!! This is the news we've all been waiting for...
User discusses potential hair loss treatment SCUBE3 and shares mixed opinions on its effectiveness. One user reports positive results after applying SCUBE3 following microneedling.
community Do you guys think it’s possible to DIY HMI-115?
Hair loss discussion includes DIY HMI-115 and its high cost (20-30k per person). Minoxidil, finasteride, and RU58841 mentioned as treatments.
community The theory that explains everything. Please help me make this big!
The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
by
nkrata
in Research
330 upvotes
1 year ago FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community Serum based on plant extracts boosts hair growth in weeks.
A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.