The Role of Smads in Skin Development

March 2008 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

P. C. Owens, Gangwen Han, Allen G. Li, Xiaojing Wang

Smads TGF-β Activin BMP signaling Smad-4 hair follicle differentiation Smad-7 hair follicle development WNT/β-catenin signaling ubiquitin-mediated β-catenin degradation TGF-beta BMP WNT signaling

Studysummary This review examines the roles of Smad-4 and Smad-7 in hair follicle differentiation and development through BMP signaling and TGFβ/Activin/BMP pathway inhibition but reports no new experimental results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes

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research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

176 citations , September 2006 in “Stem Cells”

This study found that active BMP signaling prevents epithelial stem cell activation and expansion in hair follicles, while its inhibition leads to HF stem/progenitor cell overproduction and matricomas.

research Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development

147 citations , September 2006 in “Developmental Cell”

This study found that Smad7 perturbs hair follicle development while promoting sebaceous gland formation by antagonizing Wnt/β-catenin signaling in transgenic mice.

research Stem Cells and Their Niches

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research Runx3 Is Involved in Hair Shape Determination

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This study found that Runx3 deficiency in mice affects hair type and shape, suggesting it may regulate hair formation through interactions between dermal and epidermal layers.

research BMP Signaling in the Control of Skin Development and Hair Follicle Growth

165 citations , December 2004 in “Differentiation”

This review discusses the critical role of BMP signaling in the development and regulation of skin and hair follicles and notes that further research could aid therapeutic advances; it presents no new clinical results.

research Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

250 citations , November 2003 in “The Journal of Cell Biology”

This study found that BMP receptor IA is crucial for hair progenitor cell differentiation in mice, and its sequential inhibition and activation are necessary to generate a functioning hair shaft.

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

81 citations , January 2003 in “The FASEB Journal”

This study found that follistatin and activin interactions are important for hair follicle development and cycling in mice, suggesting that they may regulate processes involving BMP-2 and its antagonist.

research Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues

111 citations , June 2002 in “The EMBO Journal”

This study found that overexpression of Smad7 in transgenic mice led to severe alterations in multiple epithelial tissues, resulting in early death after birth.

research Bone Morphogenetic Protein-2 Transactivates Dlx3 Through Smad1 and Smad4: Alternative Mode for Dlx3 Induction in Mouse Keratinocytes

79 citations , January 2002 in “Nucleic Acids Research”

This study found that BMP-2 activates Dlx3 gene transcription in murine keratinocytes by binding with Smad1/Smad4, suggesting a mechanism for BMP signaling's role in skin and hair follicle regulation.

research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

211 citations , October 2001 in “The FASEB Journal”

This study found that the BMP antagonist noggin induces hair growth in postnatal skin by neutralizing BMP4's inhibitory activity, potentially mediated by changes in Shh expression.