Expression of Signaling Components in Embryonic Eyelid Epithelium

February 2014 in “ PloS one ”

Qingxi Meng, Jin Chang, Yinglei Chen, Jing Chen, Mario Medvedovic, Ying Xia

epidermis development EGF pathway Shh pathway NOTCH pathway BMP signaling Wnt pathway epidermis epidermal growth factor sonic hedgehog bone morphogenetic protein wingless-related integration site

Studysummary This study reports differential gene expression in the leading edge and inner surface epithelial cells of murine eyelids, suggesting that distinct signaling pathways are active during embryonic eyelid closure.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on journals.plos.org →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research APCDD1 Is a Novel Wnt Inhibitor Mutated in Hereditary Hypotrichosis Simplex

199 citations , April 2010 in “Nature”

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

research Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation

578 citations , April 1993 in “Cell”

This study found that mice with a disrupted TGFα gene display a curly whisker-coat phenotype, similar to waved-1 mice, suggesting TGFα's crucial role in skin architecture and hair development.