A Guide for Building Biological Pathways with Two Case Studies: Hair and Breast Development

October 2014 in “ Methods ”

Daniel Trindade, Lissur Azevedo Orsine, Adriano Barbosa-Silva, Elisa Donnard, José Miguel Ortega

hair development biological pathways genomic information text-mining tools sub-pathways PESCADOR web interface

Studysummary This article describes how PESCADOR software assists in creating detailed biological pathway charts from PubMed abstracts, focusing on hair and breast development case studies without providing new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discussed the creation of biological pathways using genomic information and text-mining tools, aimed at users with a biological background but not necessarily experts. It provided a manual for building customized pathways, illustrated with case studies on hair and breast development, chosen for their relevance to human evolution. The study produced detailed sub-pathways for different development phases, offering more comprehensive descriptions than typical database charts. The PESCADOR web interface was highlighted as a unique tool for guiding users through biointeractions to form novel pathways.

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