A Guide for Building Biological Pathways with Two Case Studies: Hair and Breast Development

March 2015 in “ Methods ”

Daniel Trindade, Lissur Azevedo Orsine, Adriano Barbosa-Silva, Elisa Donnard, José Miguel Ortega

hair development biological pathways genomic information text-mining tools sub-pathways PESCADOR web interface

TLDR The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

The document discussed the creation of biological pathways using genomic information and text-mining tools, aimed at users with a biological background but not necessarily experts. It provided a manual for building customized pathways, illustrated with case studies on hair and breast development, chosen for their relevance to human evolution. The study produced detailed sub-pathways for different development phases, offering more comprehensive descriptions than typical database charts. The PESCADOR web interface was highlighted as a unique tool for guiding users through biointeractions to form novel pathways.

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223 citations , January 2014 in “International Journal of Molecular Sciences”

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles

14 citations , September 2013 in “Journal of dermatological science”

Hairless protein reduces Msx2 gene activity, affecting hair follicle development.

research Expression of Foxi3 Is Regulated by Ectodysplasin in Skin Appendage Placodes

43 citations , April 2013 in “Developmental dynamics”

Foxi3 expression in developing teeth and hair is controlled by the ectodysplasin pathway.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , October 2012 in “Seminars in Cell & Developmental Biology”

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

research Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

52 citations , February 2012 in “PloS one”

Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.

research Dynamic Signals for Hair Follicle Development and Regeneration

60 citations , January 2012 in “Stem Cells and Development”

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

research Gsdma3 Is Required for Hair Follicle Differentiation in Mice

30 citations , December 2010 in “Biochemical and biophysical research communications”

The Gsdma3 gene is essential for normal hair development in mice.

research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

95 citations , July 2010 in “Genes & development”

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

research Desmoglein 4 Is Regulated by Transcription Factors Implicated in Hair Shaft Differentiation

35 citations , December 2009 in “Differentiation”

Desmoglein 4 is controlled by specific proteins that affect hair growth.

research Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin

62 citations , November 2009 in “Aging Cell”

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

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81 citations , September 2009 in “Birth defects research”

Different body areas in mice produce different hair types due to interactions between skin layers.

research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

82 citations , July 2009 in “Development”

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

research Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

67 citations , February 2009 in “Developmental Biology”

Msx2 and Foxn1 are both crucial for hair growth and health.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis

102 citations , August 2008 in “Genes & Development”

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

research Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes

117 citations , August 2008 in “Developmental biology”

Ectodysplasin inhibits Wnt signaling to help form hair follicles.

research Neuregulin3 Alters Cell Fate in the Epidermis and Mammary Gland

39 citations , September 2007 in “BMC developmental biology”

Neuregulin3 affects cell development in the skin and mammary glands.

research The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis

96 citations , May 2007 in “Developmental biology”

The study found that the protein Dkk4 helps regulate hair growth by controlling Wnt signaling in mice.

research Genetic Basis of Skin Appendage Development

111 citations , April 2007 in “Seminars in cell & developmental biology”

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

65 citations , September 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Runx3 Is Involved in Hair Shape Determination

34 citations , June 2005 in “Developmental dynamics”

Runx3 helps determine hair shape.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

research The Transcriptional Repressor CDP (Cutl1) Is Essential for Epithelial Cell Differentiation of the Lung and the Hair Follicle

165 citations , September 2001 in “Genes & development”

CDP is crucial for lung and hair follicle cell development.

research The secret life of the hair follicle

745 citations , February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.