KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

    May 2009 in “ Development ”
    Gavin Richardson, Hisham Bazzi, Katherine A. Fantauzzo, James M. Waters, Heather Crawford, P. I. Hynd, Angela M. Christiano, Colin A.B. Jahoda
    Image of study
    TLDR EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.
    The study demonstrated that EGF and KGF signalling inhibited hair follicle formation and promoted interfollicular epidermal fate in developing mouse skin. Receptors for EGF and KGF were downregulated in hair follicle placodes, while their ligands persisted. Increased levels of EGFR ligands (HBEGF and amphiregulin) and the FGFR2(IIIb) receptor ligand KGF in embryonic skin organ culture inhibited follicle formation in a time- and dose-dependent manner. Molecular markers and microarray profiling indicated that KGF and EGF signalling promoted epidermal differentiation over hair follicle fate. The findings suggested that downregulation of these pathways was necessary for hair follicle initiation, revealing a new role for KGF in hair follicle formation in mice.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    3 / 3 results

      community Wtf have we been doing for the last 30 years

      in Treatment  538 upvotes 1 week ago
      Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

      community Opinions on this study for Triphasic Progressive by Rene Furterer

      in Research/Science  14 upvotes 1 year ago
      The user shared their 5-year hair loss journey, initially using a product called Triphasic Progressive by Rene Furterer, which gave good results. Later, they switched to FDA-approved medications finasteride and minoxidil, which also helped, but they noticed the most significant progress with Triphasic. They're considering trying it again if minoxidil doesn't show improvements.

      community SAFFLOWER OIL good alternative for Minoxidil?

      in Treatment  1 upvotes 4 years ago
      Safflower oil is suggested as an alternative to minoxidil for hair growth, with benefits including scalp conditioning and hair strength enhancement. Studies indicate it may also reverse scalp dermatitis, alopecia, and prevent premature grayness.

    Related Research

    3 / 3 results