KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

    May 2009 in “ Development ”
    Gavin Richardson, Hisham Bazzi, Katherine A. Fantauzzo … Colin A.B. Jahoda
    Studysummary This study found that downregulation of EGF and KGF signaling is necessary for hair follicle initiation in placodes, revealing a new role for KGF in hair follicle formation in mice.
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    Research cited in this study 12

    1. Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology American Journal Of Pathology · 2008
    2. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007
    3. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    4. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    5. Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2000
    6. Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators Developmental dynamics · 2000
    7. Specific Inhibition of Hair Follicle Formation by Epidermal Growth Factor in an Organ Culture of Developing Mouse Skin Developmental Biology · 1997
    8. Growth Factors in Hair Organ Development and the Hair Growth Cycle Dermatologic Clinics · 1996
    9. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    10. Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation Cell · 1993
    11. Targeting Expression of Keratinocyte Growth Factor to Keratinocytes Elicits Striking Changes in Epithelial Differentiation in Transgenic Mice The EMBO Journal · 1993
    12. Immunolocalization of Epidermal Growth Factor Receptors in Normal Developing Human Skin Journal of Investigative Dermatology · 1990

    Related research 4

    1. Endogenous Human Skin Equivalent Promotes In Vitro Morphogenesis of Follicle-Like Structures Biomaterials · 2016
    2. KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin Development · 2009
    3. α3β1-Integrin Regulates Hair Follicle But Not Interfollicular Morphogenesis in Adult Epidermis Journal of Cell Science · 2003
    4. Localization of Epidermal Growth Factor Immunoreactivity in Sheep Skin During Wool Follicle Development Journal of Investigative Dermatology · 1992