The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis

    March 2007 in “ Developmental biology ”
    Hisham Bazzi, Katherine A. Fantauzzo, Gavin Richardson, Colin A.B. Jahoda, Angela M. Christiano
    TLDR The study found that the protein Dkk4 helps regulate hair growth by controlling Wnt signaling in mice.
    The study investigated the role of the Wnt inhibitor Dickkopf 4 (Dkk4) in ectodermal appendage morphogenesis, particularly hair follicle (HF) development. Researchers found that Dkk4 is induced by canonical Wnt signaling and is transiently expressed during the pre-placode stage of appendage formation, suggesting a negative feedback mechanism to regulate HF patterning. Experimental validation showed that Dkk4 is a target of Wnt signaling, with LEF1/β-catenin complexes binding to its promoter. The study proposed that Dkk4 might also facilitate a switch from canonical to non-canonical Wnt signaling, influencing cell movements during HF morphogenesis.
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