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    GlossaryWnt inhibitor

    substance that blocks cell growth and differentiation signals

    A Wnt inhibitor is a substance that blocks the Wnt signaling pathway, which is crucial for various cellular processes, including cell growth and differentiation. In the context of hair biology, inhibiting the Wnt pathway can affect hair follicle development and regeneration, potentially influencing conditions like alopecia (hair loss).

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      learn Follistatin

      glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

      learn KY19382

      compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

      learn Estradiol

      an estrogen promoting hair regrowth more commonly used in women

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      community Anyone here holding out for Breezula?

      in Treatment  6 upvotes 4 years ago
      The conversation is about individuals considering waiting for Breezula to treat hair loss instead of using Finasteride due to concerns about side effects. Some are opting for Finasteride now, while others are wary of its impact on neurosteroids.

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  40 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Ultimate anti-DHT solution

      in Treatment  3 upvotes 3 years ago
      A 25-year-old male experiencing hair loss and thinning since age 20 is seeking advice on effective DHT inhibitors. He lists various oral and topical treatments, excluding Minoxidil due to adverse effects.