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    Glossary Wnt inhibitor

    substance that blocks cell growth and differentiation signals

    A Wnt inhibitor is a substance that blocks the Wnt signaling pathway, which is crucial for various cellular processes, including cell growth and differentiation. In the context of hair biology, inhibiting the Wnt pathway can affect hair follicle development and regeneration, potentially influencing conditions like alopecia (hair loss).

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    1. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis Developmental biology · 2007 · 96 citations
    2. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles PLOS Biology · 2018 · 68 citations
    3. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis Development · 2011 · 59 citations
    4. 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment Journal of Investigative Dermatology · 2017
    5. LncRNA H19 inhibited dermal papilla cell senescence process through miR-29a by targeting Wnt/β-catenin signaling pathway Archives of Dermatological Research · 2025
    6. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex Nature · 2010 · 199 citations
    7. 726 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning Journal of Investigative Dermatology · 2022
    8. 318 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning Journal of Investigative Dermatology · 2021
    9. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    10. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
    11. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/β-Catenin Pathway Stem Cells International · 2023
    12. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes Developmental biology · 2008 · 117 citations
    13. 0935 Endogenous secreted Wnt inhibitors suppress hair follicle neogenesis in postnatal skin Journal of Investigative Dermatology · 2026
    14. Platelet-Rich Plasma Contains High Concentrations of DKK1, A Potent Inhibitor of Wnt Signaling that Limits Bone Regeneration and Hair Growth Journal of orthopedics & bone disorders · 2023
    15. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations
    16. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk Nature Communications · 2014 · 51 citations
    17. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways American Journal Of Pathology · 2009 · 45 citations
    18. Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration Histochemistry and Cell Biology · 2017 · 30 citations
    19. Exosomal miRNA-181a-5p from the cells of the hair follicle dermal papilla promotes the hair follicle growth and development via the Wnt/β-catenin signaling pathway International journal of biological macromolecules · 2022 · 25 citations
    20. Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems Stem Cell Research & Therapy · 2019 · 17 citations
    21. Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling American Journal of Pathology · 2020 · 15 citations
    22. Urotensin II promotes the proliferation and secretion of vascular endothelial growth factor in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway Italian Journal of Medicine · 2023
    23. The role of Wnt and Shh signaling systems in noggin-induced tumorigenesis Vestnik Rossijskogo universiteta družby narodov. Seriâ Agronomiâ i životnovodstvo · 2024
    24. Faculty Opinions recommendation of Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    25. Wnt is back in drugmakers' sights, but is it druggable? Nature Biotechnology · 2018 · 10 citations
    26. First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours. Journal of Clinical Oncology · 2017 · 33 citations
    27. The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 16 citations
    28. 845 Dermal lymphatic vessels promote hair follicle growth via the BMP inhibitor Sostdc1 Journal of Investigative Dermatology · 2017
    29. 612 Wnt signaling induces fibrotic fat loss via DPP4 in skin fibrosis Journal of Investigative Dermatology · 2021
    30. Hairless triggers reactivation of hair growth by promoting Wnt signaling Proceedings of the National Academy of Sciences of the United States of America · 2005 · 137 citations