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    Glossary Wnt inhibitor

    substance that blocks cell growth and differentiation signals

    A Wnt inhibitor is a substance that blocks the Wnt signaling pathway, which is crucial for various cellular processes, including cell growth and differentiation. In the context of hair biology, inhibiting the Wnt pathway can affect hair follicle development and regeneration, potentially influencing conditions like alopecia (hair loss).

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    1. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis Developmental biology · 2007 · 96 citations
    2. Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles PLOS Biology · 2018 · 68 citations
    3. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis Development · 2011 · 59 citations
    4. Circ-Smad5 retards the G1/S transition of cell cycle via inhibiting the activity of wnt/lef/cyclind1 signaling in JB6 cells Genes & Diseases · 2020 · 10 citations
    5. 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment Journal of Investigative Dermatology · 2017
    6. LncRNA H19 inhibited dermal papilla cell senescence process through miR-29a by targeting Wnt/β-catenin signaling pathway Archives of Dermatological Research · 2025
    7. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex Nature · 2010 · 199 citations
    8. 726 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning Journal of Investigative Dermatology · 2022
    9. 318 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning Journal of Investigative Dermatology · 2021
    10. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    11. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
    12. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/β-Catenin Pathway Stem Cells International · 2023
    13. Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice Journal of diabetes research · 2022 · 6 citations
    14. Anti-androgenetic effect of diphlorethohydroxycarmalol on testosterone-induced hair loss by inhibiting 5α-reductase and promoting Wnt/β-catenin signaling pathway in human dermal papilla cells Toxicology in Vitro · 2025 · 1 citations
    15. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes Developmental biology · 2008 · 117 citations
    16. 0935 Endogenous secreted Wnt inhibitors suppress hair follicle neogenesis in postnatal skin Journal of Investigative Dermatology · 2026
    17. Platelet-Rich Plasma Contains High Concentrations of DKK1, A Potent Inhibitor of Wnt Signaling that Limits Bone Regeneration and Hair Growth Journal of orthopedics & bone disorders · 2023
    18. Effects of Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose on androgenic alopecia via inhibiting 5a-reductase and regulating Wnt/β-catenin pathway Fitoterapia · 2024
    19. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations
    20. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk Nature Communications · 2014 · 51 citations
    21. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways American Journal Of Pathology · 2009 · 45 citations
    22. Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration Histochemistry and Cell Biology · 2017 · 30 citations
    23. Exosomal miRNA-181a-5p from the cells of the hair follicle dermal papilla promotes the hair follicle growth and development via the Wnt/β-catenin signaling pathway International journal of biological macromolecules · 2022 · 25 citations
    24. Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems Stem Cell Research & Therapy · 2019 · 17 citations
    25. Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling American Journal of Pathology · 2020 · 15 citations
    26. Urotensin II promotes the proliferation and secretion of vascular endothelial growth factor in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway Italian Journal of Medicine · 2023
    27. The role of Wnt and Shh signaling systems in noggin-induced tumorigenesis Vestnik Rossijskogo universiteta družby narodov. Seriâ Agronomiâ i životnovodstvo · 2024
    28. Faculty Opinions recommendation of Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    29. Wnt is back in drugmakers' sights, but is it druggable? Nature Biotechnology · 2018 · 10 citations
    30. First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours. Journal of Clinical Oncology · 2017 · 33 citations