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    Glossary Dickkopf-1

    inhibits hair follicle formation, contributing to hair loss

    Dickkopf-1 (DKK1) is a protein that plays a crucial role in regulating cell signaling pathways, particularly the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, DKK1 is known to inhibit hair follicle formation and is associated with conditions like androgenetic alopecia (pattern baldness), where its elevated levels can lead to hair loss.

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    1. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    2. Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells BMB Reports · 2010 · 31 citations
    3. I‐Ascorbic acid 2‐phosphate represses the dihydrotestosterone‐induced dickkopf‐1 expression in human balding dermal papilla cells Experimental Dermatology · 2010 · 13 citations
    4. Assessment of tissue levels of dickkopf-1 in androgenetic alopecia and alopecia areata Journal of Cosmetic Dermatology · 2015 · 10 citations
    5. Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients American Journal of Dermatopathology · 2019 · 9 citations
    6. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    7. Attenuation of Dickkopf 1-Induced Hair Growth Inhibition in Cultured Human Hair Follicles by Tianeptine Annals of Dermatology · 2017 · 4 citations
    8. Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells BMB Reports · 2010 · 2 citations
    9. Serum Dicckopf-1 Level in Patients of Cicatricial and Non- Cicatricial Alopecia Benha Journal of Applied Sciences · 2022
    10. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis Developmental biology · 2007 · 96 citations
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    1. NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress Reddit · 9 Jun 2024

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