Minoxidil can prevent hairfollicleminiaturization, not just stimulate hair growth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hair loss; hair loss could be due to multiple factors, including autoimmune conditions.
DHT may inhibit hair growth by affecting mitochondrial function, leading to hairfollicleminiaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.
Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicleminiaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.
The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hairfollicleminiaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.
Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.