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    GlossaryHair Follicle Miniaturization

    hair follicles shrink, producing thinner and shorter hair strands

    Hair Follicle Miniaturization is a process where hair follicles gradually shrink, producing thinner and shorter hair strands over time. This phenomenon is commonly associated with androgenetic alopecia (pattern baldness) and can eventually lead to the cessation of hair growth in the affected follicles.

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      learn Minoxidil

      An essential vasodilator with some anti-androgenic effects, has excellent safety record

      learn Fluridil

      a topical anti-androgen with less systemic involvement

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn Alfatradiol

      a synthetic estrogen used topically as an anti-androgen

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      community Minoxidil can prevent hair follicle miniaturization!?

      in Minoxidil  6 upvotes 3 years ago
      Minoxidil can prevent hair follicle miniaturization, not just stimulate hair growth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hair loss; hair loss could be due to multiple factors, including autoimmune conditions.

      community Pyrilutamide phase III clinical trial results released

      in Research/Science  31 upvotes 11 months ago
      Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicle miniaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  22 upvotes 8 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.